No. Authors [Ref] Year Type of study
Results 1 Chen et al. [17 ] 2011 Cross-sectional 102 Severity of OSA is associated with increased homocysteine levels in subjects with ischemic heart disease 2 Basoglu et al. [14 ] 2011 Case control 36 cases, 34 controls No association between plasma homocysteine and OSA in obese patients 3 Cintra et al. [18 ] 2011 Matched case control 75 cases, 75 controls Cysteine but not homocysteine is differentially distributed across OSA and non-OSA patients 4 Wang et al. [27 ] 2010 Cross-sectional 83 patients with OSA, 52 without OSA Oxidative stress might induce high plasma homocysteine levels in elderly patients with OSA 5 Cerbo et al. [16 ] 2010 Case report 1 Early onset homocystinuria is associated with apneic spells 6 Sariman et al. [25 ] 2010 Cross-sectional 38 cases of OSA Plasma homocysteine levels correlate with the severity of OSA 7 Yavuz et al. [28 ] 2008 Cross-sectional 62 patients of OSA, 12 controls Plasma homocysteine levels are elevated in patients with OSA 8 Ozkan et al. [23 ] 2008 Cross-sectional 34 OSA patients, 15 controls Plasma homocysteine levels are raised in patients with severe OSA 9 Ryan et al. [24 ] 2007 Cross-sectional 80 patients with OSA, 30 controls Plasma homocysteine levels are not associated with either the risk or severity of OSA 10 Kumor et al. [21 ] 2006 Cross-sectional 47 patients of OSA, 12 controls Plasma homocysteine levels are not differentially distributed across patients and controls of OSA 11 Hachul de Campos et al. [19 ] 2006 Cross-sectional 38 insomniac postmenopausal women Plasma homocysteine levels are not associated with risk of apnea 12 Can et al. [15 ] 2006 Cross-sectional 30 OSA patients, 32 controls Serum homocysteine levels are significantly higher in OSA patients 13 Kokturk et al. [20 ] 2006 Cross-sectional 72 OSA patients, 42 controls Serum homocysteine is significantly increased in patients with OSA 14 Svatikova et al. [26 ] 2004 Case control 22 OSA patients, 20 controls Plasma homocysteine levels exhibit diurnal variation and are not differentially distributed across patients and controls of OSA 15 Lavie et al. [22 ] 2001 Case control 237 cases of OSA, 108 controls Patients with ischemic heart disease and OSA have elevated plasma homocysteine levels
