Fast-Acting Sublingual Zolpidem for Middle-of-the-Night Wakefulness

Table 1

Zolpidem products currently marketed in the United States for treatment of insomnia. Zolpidem 10 mg tablets are marketed in Australia under the trade name Stilnox.

Brand Name	Manufacturer	Formulation	Indication	Strength(s)
Ambien [58]*	Sanofi	Immediate-release tablet	Difficulty with sleep initiation	5 and 10 mg
Ambien CR [59]	Sanofi	Controlled-release tablet (sometimes called extended-release or modified-release Ambien)	Difficulty with sleep onset and/or sleep maintenance	6.25 and 12.5 mg
Edluar [60]	Meda	Sublingual tablet	Difficulty falling asleep	5 and 10 mg
Intermezzo [19]	Transcept/Purdue Pharma	Fast-acting sublingual tablet	Middle-of-the-night wakefulness and difficulty returning to sleep	1.75 and 3.5 mg
Zolpimist [61]	NovaDel/ECR	Oral spray	Difficulty with sleep initiation (also being studied for middle-of-the-night wakefulness)	5 mg

All brand names are trademarks or registered trademarks of the manufacturer or drug owner.
*The patent on the Ambien immediate-release formulation has expired and generic products have been introduced into the market.