Sleep Disorders / 2014 / Article / Tab 2 / Review Article
Fast-Acting Sublingual Zolpidem for Middle-of-the-Night Wakefulness Table 2 Pharmacokinetic parameters for zolpidem formulations.
Brand name AUC(ng
h/mL)
(ng/mL)
(hours)
(hours)Protein binding Nonbenzodiazapines Ambien* 5 and 10 mg, respectively [58 ] 59 (range 29–113) and 121 (range 58–272) 1.6 for both 2.6 (range 1.4–4.5) and 2.5 (range 1.4–3.8) 92.5 ± 0.1% Ambien CR 12.5 mg [59 ] 740 ng
hr/mL (range: 295 to 1359 ng
hr/mL) 134 (range 68.9–197) 1.5 Similar to above 92.5% ± 0.1% Edluar 10 mg [60 ] 106 (range 52–205) 1.4 2.65 (range 1.75–3.77) 92.5% ± 0.1% Intermezzo 3.5 mg [21 ] Healthy Men: 198 Women: 296 *Elderly & hepatic impaired may vary 3.5 mg: men 53 and women 77. *Elderly & hepatic impaired may vary 0.6 to 1.25 2.5 (range 1.4 to 3.6) 93% ± 0.1% Zolpimist 5 and 10 mg [61 ] 114 (range 19–197) and 210 (range 77–401), respectively 0.9 for both 2.7 (range 1.7–5.0) and 3.0 (range 1.7–8.4), respectively 92.5% ± 0.1% Benzodiazapines Triazolam (Halcion) [62 ] 1–6 2 1.5–5.5 Temazepam (Restoril) (30 mg) [63 ] 666 to 982 ng/mL (mean 865 ng/mL) 1.2 to 1.6 hours (mean 1.5 hours) 4–18 96
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*The patent on the Ambien immediate-release formulation has expired and generic products have been introduced into the market.