| | Research studies | Oxygen desaturation index (mean/SD, except) | Lowest oxygen saturation (mean/SD except) | | Author, year | Pre-NEPAP | Post-NEPAP | MD (95% CI) | value | Pre-NEPAP | Post-NEPAP | MD (95% CI) | value |
| | Colrain et al., 2008 [12] | 14.6 ± 16.9 | 9.9 ± 15.2 | −4.70 (−13.007, 3.607) | 0.2621 | 82.6 ± 8.6 | 85.3 ± 8.4 | 2.70 (1.693, 7.093) | 0.2236 | | Rosenthal et al., 2009 [16] | 11.0 ± 17.5 | 9.2 ± 14.3 | −1.80 (−10.363, 6.763) | 0.6751 | 85.0 ± 7.4 | 85.1 ± 8.1 | 0.10 (−3.96, 4.16) | 0.9617 | | Hwang et al., 2009 [20] | — | — | — | — | — | — | — | — | | Westbrook et al., 2009 [21] | — | — | — | — | — | — | — | — | | Berry et al., 2011 [18] | 12.6 | 8.6 | — | — | — | — | — | — | | Kryger et al., 2011 [19] | 12.6 | 7.6 | — | — | — | — | — | — | | Patel et al., 2011 [13] | — | — | — | — | — | — | — | — | | Walsh et al., 2011 [17] | 38.8 ± 27.2 | 17.0 ± 11.3 | −21.80 (−30.732, −12.868) | 0.0001 | — | — | — | — | |
Adams 2011 [22] | — | — | — | — | — | — | — | — | | Hwang et al., 2011 [23] | 21.8 ± 13.0 | 12.1 ± 10.3 | −9.70 (−15.213, −4.187) | 0.0008 | — | — | — | — | |
Massie and Hart 2011 [24] | 18.8 | 4.4 | — | — | — | — | — | — | | Adams 2012 [25] | — | — | — | — | — | — | — | — | |
Massie 2012 [26] | 13.7 | 8.2 | — | — | — | — | — | — | | Rossi et al., 2013 [14] | 33.1 ± 12.2 | 35.8 ± 17.4 | 2.70 (−6.672, 12.072) | 0.5637 | — | — | — | — | | Deoras et al., 2013 [27] | — | — | — | — | — | — | — | — | | Mansfield et al., 2013 [28] | — | — | — | — | — | — | — | — | | Martin et al., 2014 [29] | 13.8 ± 11.4 | 5.0 ± 5.8 | −8.80 (−12.4, −5.3) | <0.00001 | 84.0 ± 5.0 | 86.7 ± 16.2 | 2.70 (−2.0, 7.45) | 0.2629 | | Friedman et al., 2015 [15] | 16.3 ± 10.8 | 8.2 ± 9.0 | −8.10 (−12.644, −3.556) | 0.0007 | 81.3 ± 6.7 | 86.9 ± 5.6 | 5.60 (2.777, 8.423) | 0.0002 | | Combined means | 21.2 ± 19.3 | 12.4 ± 14.1 | −8.80 (−11.78, −5.82) | <0.00001 | 83.2 ± 6.8 | 86.2 ± 11.1 | 3.00 (0.89, 5.11) | 0.005 |
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