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Smart Materials Research
Volume 2012 (2012), Article ID 264609, 8 pages
http://dx.doi.org/10.1155/2012/264609
Research Article

Drug Release Kinetics from Polymer Matrix through Fractal Approximation of Motion

1Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University, Prof. Dr. Docent Dimitrie Mangeron Road, No. 73, 700050 Iasi, Romania
2Physics Department, Faculty of Machine Manufacturing and Industrial Management, “Gheorghe Asachi” Technical University, Prof. Dr. Docent Dimitrie Mangeron Road, No. 59A, 700050 Iasi, Romania
3Centre of Advanced Researches for Bionanoconjugates and Biopolymers, “Petru Poni” Institute of Macromolecular Chemistry, Grigore Ghica Voda Avenue, No. 41A, 700487 Iasi, Romania
4Lasers, Atoms and Molecules Physics Laboratory, University of Science and Technology, Villeneuve d’Ascq, 59655 Lille, France

Received 10 February 2012; Revised 4 March 2012; Accepted 5 March 2012

Academic Editor: Metin Ak

Copyright © 2012 S. Băcăiţă et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present paper analyzes the process of drug release from polymer matrix. This process has been considered as fractal polymer process. Since complexity of physical processes is replaced by fractality, the paper studies the process through fractal approach. In drug dynamics, fractal “diffusion” equation can be obtained through fractal approximation of motion. All experimental release curves have been best demonstrated by Weibull relation (which was, in its turn, also demonstrated). Weibull parameters are related to the fractal dimension of drug release kinetics from a polymer matrix. Such a dimension can characterize and measure the complexity of the system. In the above-mentioned context, some experimental results of our researchers are presented and analyzed by comparing them with Peppas relation, a basic law in the description of drug release kinetics. Consequently, experimental data for Weibull relation are better correlated with certain resulting factors. At the same time, some conclusions regarding the phenomena involved in the process are considered as being based on the approach.