- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Spectroscopy
Volume 24 (2010), Issue 3-4, Pages 191-195
doi:10.3233/SPE-2010-0461
Abnormal shifts in Raman spectra of deuterated cytidine and 6-azacytidine
1Department of Physics, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
2Department of Physics, Taras Shevchenko National University of Kyiv, 64 Volodymyrs'ka St., 01033 Kyiv, Ukraine
Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
It was revealed that some peaks in Raman spectra of cytidine, 6-azacytidine (6-azaC), and cytosine dissolved in D2O are shifted to high frequencies in respect to their positions in spectra of H2O solution. Such “blue shifts” occur due to deuteration of the nucleoside molecule itself but not due to effect of deuterated solvent. This conclusion is deduced from observation of blue (abnormal) shift in Raman spectra of cytidine and 6-azaC microcrystals recrystallized from D2O solution. Both normal and abnormal shifts close to the experimentally observed were obtained in the calculated spectra of 6-azaC and cytidine. We assume that abnormal shifts may be caused by substitution of intramolecular H-bonds with D-bonds.