Cannabinoids for the Treatment of Schizophrenia? A Balanced Neurochemical Framework for Both Adverse and Therapeutic Effects of Cannabis Use

Table 1

Directions of neurotransmitter release in the prefrontal cortex and subcortical regions.

	Prefrontal cortex			Subcortical regions
	Schizophrenia (unmedicated)	Atypical antipsychotic treatment	Cannabis use	Schizophrenia (unmedicated)	Atypical antipsychotic treatment	Cannabis use
Dopamine
Serotonin
Acetylcholine
Noradrenaline
Glutamate
GABA