Faulty Suppression of Irrelevant Material in Patients with Thought Disorder Linked to Attenuated Frontotemporal Activation
Figure 2
(a) 3-Group ANOVA: semantic congruency (congruent versus incongruent) trials. Comparison of healthy controls () versus schizophrenic patients with formal thought disorder (FTD, ) versus schizophrenic patients without formal thought disorder (Non-FTD, ). Attenuated activation in the left inferior frontal gyrus was observed in FTD relative to Non-FTD and to controls. The latter showed greater activation in this region also relative to non-FTD. The left side of the brain images corresponds to the right side of the brain. The superior part of the brain images corresponds to the anterior brain region. (b) Scatter plot of the activity in the left inferior frontal cortex as a function of the score in formal thought disorder (FTD) within schizophrenic patients (). We observe that FTD higher scores in a sample of psychotic schizophrenic patients are negatively correlated with activity in the left inferior frontal cortex ().
