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Table 1: Outpatient DSRCT chemotherapy: doses and schedule.

Agent Dose Route Comments Preadjuvant phase of therapy (every 3 weeks 4 cycles) Vincristine 1.5 mg/m2 iv over 2–15 minutes Max dose 2 mg; day 1 only Etoposide 150 mg/m2 iv over 1 hour Day 1 only Dexrazoxane 750 mg/m2 iv over 15 minutes Just before doxorubicin Doxorubicin 75 mg/m2 iv over 15 minutes Day 1 only Ifosfamide 3 g/m2 iv daily 3 Continuous infusion. Mix + MESNA 3 g/m2 iv daily 4 with MESNA in 240–360 mL NS days 1, 2, 3. MESNA only day 4 (portable pump as outpatient) CHPP phase Cisplatin 100 mg/m2 Intraperitoneal As continuous peritoneal perfusion at 42°C 1.5 hr Radio sensitization during RT Temozolomide 75 mg/m2 po Daily 5 2 weeks Bevacizumab 5 mg/kg iv q2 weeks 2 doses begin before RT Pre-RT (2 cycles) and post-RT (10 cycles) Temozolomide 100 mg/m2 po Daily 5 each month Irinotecan 10 mg/m2 iv Daily 5 2 weeks each month; may do as home infusions Chronic continuation chemotherapy Valproate 500 mg/m2 po Daily; divide BID monitor level <100 Rapamycin 2 mg/m2 po Daily round to nearest mg Cyclophosphamide 25 mg po If >1.5 m2 may give 50 mg daily. Monitor cbc