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Table 1: Characteristics of the 52 patients with MPNST. NF1: Neurofibromatosis type 1; Spo: sporadic form of NF1 (no familial history), Fam: familial form of NF1; L: local stage; LA: locally advanced stage; Met: metastatic stage. A: alive. D: dead; +: positive staining; −: negative staining; n.e.: not evaluable staining.

Patient NF1 Age/gender Stage init Localization EGFR R72 no 37/m LA Neck + R69 no 12/m LA Thigh + R92 no 11/w LA Brachial plexus + R78 no 28/w L Left arm + R94 no 52/m L Ethmoid + R86 no 33/f L Arm + R87 no 3/f L Tibial nerve + R77 no 71/f L Median nerve + R84 no 19/m LA Pelvis + R90 no 47/m L Right thigh + R74 no 16/f L Foot + R85 no 48/f L Forearm + R93 no 7/f L Mandible + R79 no 30/m L Wrist + R89 no 18/f LA Infratemporal fossa + R88 no 26/m L Left calf 0 R75 no 50/f LA Retroperitoneum 0 R76 no 23/m L Frontal region 0 B1027 no 15/m LA Retroperitoneum, pelvis 0 R73 no 7/m LA Neck 0 B1499 no 60/m LA Mediastinum n.e. R80 no 14/f L Left orbit n.e. B1044 no 7/m L Calf n.e. R95 no 20/m Met Hand n.e. R81 no 46/m L Forearm n.e. B1463 no 19/m LA Armpit n.e. R123 Fam 15/m L Median nerve + R118 B Fam 11/f LA Brachial plexus + B1357 Spo 16/m LA Sciatic nerve + R107 Spo 33/m L Neck + R111 Spo 13/f LA Thigh + B1064 Spo 44/f L Thigh + R116 Spo 10/m LA Arm + R98 Spo 23/f L Calf + B2387 Spo 29/m LA Supraclavicular region + R122 Fam 19/f LA Groin + R104 Spo 25/m L Left calf + R97 Spo 17/m LA Left iliac + B1400 Fam 20/m LA Chest wall + R105 Spo 13/m LA Abdominal wall + R96 Spo 23/m LA Sciatic nerve buttock + R102 Spo 23/m Méta Retroperitoneum + R101 Spo 26/m LA Retroperitoneum + B1399 Spo 5/m LA Urinary bladder + R114 Spo 7/m LA Thigh + B1148 Fam 17/f L Thigh + bloc t Spo 32/f L Thigh + B1793 Fam 32/f L Thigh 0 R127 Fam 11/f LA Left thigh (sciatic) n.e. R119 Fam 10/m LA Retroperitoneum n.e. R125 Fam 11/f LA Upper n.e. B1599 Spo 20/f LA Pelvis n.e.