Human Chondrosarcoma Cells Acquire an Epithelial-Like Gene Expression Pattern via an Epigenetic Switch: Evidence for Mesenchymal-Epithelial Transition during Sarcomagenesis
Figure 5
The maspin promoter and 14-3-3σ gene are hypomethylated in mRNA expressing chondrosarcoma cell lines. Bubble charts of the maspin promoter (a) and 14-3-3σ gene (b) for the five chondrosarcoma cell lines analyzed. Each of the five rows represents a sequenced amplicon while each column represents the nucleotide position of the CpG measured relative to the transcription start site. Darkened circles represent methylated cytosines, and clear circles represent unmethylated cytosines. Nucleotide positions relative to start site were based on UCSC genome browser build 17.
