Global Gene Expression Profiling of Human Osteosarcomas Reveals Metastasis-Associated Chemokine Pattern

Table 3

GO groups with significant enrichment, based on a comparison of the top-210 significant genes differentially expressed between metastases and primary tumours against all genes present on the microarray. The number of genes in the total list and observed and expected number of genes in the gene list that map to the GO group are shown. + or − signs indicate over- or underrepresentation, respectively, of this GO group. 𝑃-values were Bonferroni corrected for multiple testing, 𝑃-value < 0.05.

GO group	# Genes total	Gene list
		# Observed	# Expected	+/−	𝑃-value
Biological process
Immunity and defence	1365	30	11.3	+	3.7E–5
Granulocyte mediated immunity	59	6	0.5	+	1.7E–3
Macrophage mediated immunity	126	8	1.1	+	1.8E–3
Cell proliferation and differentiation	944	20	7.8	+	4.2E–3
Blood circulation and gas exchange	82	5	0.7	+	2.0E–2
Cell cycle control	390	12	3.2	+	1.7E–2
JNK cascade	60	5	0.5	+	3.2E–2
Molecular function
Surfactant	9	5	0.7	+	2.8E–6
Chemokine	45	5	0.4	+	6.8E–3
Interleukin	34	4	0.3	+	4.1E–2