Review Article
Recanalization Therapies in Acute Ischemic Stroke: Pharmacological Agents, Devices, and Combinations
Table 1
Arterial occlusions and recanalization patterns in some clinical trials in acute ischemic stroke.
| TRIAL | Treatment | Number of patients | Highest reported recanalization rate (%) | Assessment of recanalization |
| NINDS | Active | IV-TPA | 312 | — | None | Control | Placebo | 312 | — |
| DIAS | Active | | Desmopletase (IV) | 71 (Total) | 49 | MRA-complete or partial recanalization | Part-l | 25 mg | 16 | 56 | | 37.5/50 mg | 13 | 46 | Part-2 | 62.5 mg/kg | 13 | 23 | | 90 mg/kg | 15 | 47 | | 125 mg/kg | 14 | 71 | Control | | Placebo | 26 (Total) | 19 | Part-1 | | | 16 | 19 | Part-2 | | | 10 | 20 |
| PROACT-II (TIMI 2 3) | Active | | lAr-proUK | 121 | 66 | Cerebral angiography (TIMI 2 3) | Control | | Placebo | 59 | 18 |
| EMS | Active | | IV IA TPA | 11 | 81 | Cerebral angiography | Control | | Placebo IA TPA | 10 | 50 |
| MERCI | Active | | MERCI Lytic | | | Cerebral angiography (any recanalization) | MCA | | | 80 | 45 | ICA | | | 47 | 53 | VAIBA | | — | 14 | 50 | Control | | | — | — |
| CLOTBUST (at 2 hours) | Active | | IV-TPA TCD | 63 | 38 | TCD | Control | | IV-TPA | 63 | 13 |
| TRUMBI | Active | | IV-TPA Ultrasound | 14 | 29.3 | MRA | Control | | IV-TPA | 12 | 50.0 |
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