|
| Author’s name/study name | Outcome | Gene (Variant) | Sample Size/drug | Effect estimates and findings |
|
Broderick et al.
2001 [26] | Favourable outcome (NIHSS of 0 or 1, Barthel Index of 95 or 100, Modified Rankin Scale of 0 or 1, and a Glasgow Outcome Scale of 1.) | ApoE (E2, E3, E4) | 409 ischemic stroke/rTPA versus PB
within 3 hours | ApoE E2 phenotype-rt-PA interaction was associated with good outcome at 3 months (OR: 6.4; 95% CI: 2.7–15.3).
Apo E4 phenotype not related to favorable 3 month outcome, response to t-PA, 3-month mortality, or risk of intracerebral hemorrhage |
|
| Fernández-Cadenas et al. [27] | Recanalization rate, NIHSS at 48 hours and mRS score at 3 months, heamorrhagic transformation | ApoE (E2, E3, E4) | 77 ischemic stroke/rTPA within 3 hours | No significant association of ApoE genotype and the studied outcome |
|
| Del Río Espínola et al. [28] | Reocclusion rate | 236 SNPs form candidate genes for vascular risk factor | 222 ischemic stroke/rTPA | rs1883832 SNP from CD40 gene (OR: 0.077; 95% CI: 0.009–0.66) and rs1800801 SNP from the MGP gene (OR 15.25; 95% CI: 2.23–104.46) were independently associated with reocclusion after adjustment for clinical predictors |
|
| Fernández-Cadenas et al. [29] | Recanalization | ACE (I/D) | 96 ischemic stroke/rTPA
within 3 hours | ACE DD homozygosis was significantly associated with recanalization rate following rTPA (OR: 4.3 95% CI: 1.35–13.49).
No relation was found between ACE I/D polymorphism and symptomatic hemorrhagic complications. No association between ACE genotypes and Factor VII or Factor X activities |
|
| Fernández-Cadenas et al. [30] | Recanalization | PAI-1 4G/5G
TAFI (Thr325Ile) | 139 with ischemic stroke/TPA within 3 hours | PAI-1 4 G/5 G was not associated with recanalization.
TAFI Thr325Ile polymorphism was associated with recanalization resistance (OR 5.6 95% CI 1.2–20). Combination of TAFI and PAI-1 polymorphisms double the risk of absence of recanalization (OR: 11.1; 95% CI: 1.4–89.8) |
|
| González-Conejero et al. [31] | Death, recanalization | Factor XIII (FXIII) V34L | 200 with ischemic stroke/TPA within 3 hours | FXIII 34 L carriers had higher death risk than V/V (OR 2.50 95% CI 1.00–7.06); high fibrinogen levels higher risk than lower levels (OR 2.72 95% CI 1.01–7.44); FXIII 34L and high fibrinogen level higher risk than FXII V and low fibrinogen (OR 5.74 95% CI 1.51–11.56).
No difference in recanalization rate |
|
| Montaner et al. [32] | Hemorrhagic transformation | MMP9 (C1562T) | 61 with ischemic stroke/TPA within 3 hours | The polymorphism studied does not increase hemorrhagic risk |
|
