Cumulative probability of ischemic strokes in target artery territory, including any stroke and death within 30 days, was 8.8% at yrs 1-2. Among elective cases no procedure related deaths
Ischemic stroke rate was 4.3 per 100 patient years. 1 patient (2.2%, 1/46) developed minor ischemic stroke in the target-lesion artery territory at 6.7 months, which was related to angiographically verified restenosis
1377 (714 assigned to best medical care and 663 with medical care+Bypass)
14% conversion from stenosis to occlusion of MCA
30 day surgical mortality rate 0.6%
Perioperative strokes in medical group 1.3%
Medical therapy+EC-IC Bypass
Postoperative bypass patency rate at median 32 days 96%
Peri-operative mortality rate 1.1%
4.5% in surgical group 30 day major stroke morbidity rate 2.5%
†Primary end points: death, ischemic stroke, major hemorrhage, or death from vascular causes other than stroke. Secondary end points: ischemic stroke or brain hemorrhage, ischemic stroke, Ischemic stroke in territory of stenotic artery, disabling or fatal ischemic stroke, ischemic stroke, myocardial infarction, or death from vascular causes other than stroke. ‡Except in one case where 66% residual stenosis was left and ipsilateral stroke occurred after 7 months. μProgression: worsening of stenosis by 1 or more grade on final MRA compared to the baseline MRA. Regression: improvement of stenosis by 1 or more grade.
*Rate of stroke in patients with carotid siphon or MCA stenosis. ¥Ischemic stroke or brain hemorrhage. ∧Ischemic stroke. ††Ischemic stroke in the territory of stenotic artery. ¶Disabling or fatal ischemic stroke.
***Ischemic stroke, myocardial infarction, or death from vascular causes other than stroke. ∞Death from vascular causes.
**Death from nonvascular causes. ®Major hemorrhage. ®®Myocardial infarction.