Table 1: Modifications of haemostatic factors during pregnancy.

Procoagulant factors  Fibrinogen (factor I)  von Willebrand factor  Factors VII, VIII, IX, X, XII  Factors V, XIII  Factor XI C  Factor II C Coagulation inhibitors  Protein S  Protein C, antithrombin III = Fibrinolytic factors  Tissue plasminogen activator  Plasminogen activator inhibitor 1 and 2 (PAI-1, PAI-2)  Thrombin activatable fibrinolysis inhibitor (TAFI) Others  Platelet count  Prothrombin fragment 1+2  Thrombin-antithrombin complex  D-dimer, fibrinopeptide-A

: increase; : decrease; =: no significant change; : early increase followed by decrease; C: controversial data.