Table 2: Univariate associations of laboratory markers of infection with the development of an infection and serious infection during the hospital stay.

No infection   𝑁 = 5 5 Infection   𝑁 = 3 9 𝑃 Serious infection   𝑁 = 1 9 𝑃 * Normal Range

Markers of Infection

Mean temperature day 1 (°C) 3 6 . 7 ± 0 . 1 3 7 . 4 ± 0 . 1 <.0001 3 7 . 4 ± 0 . 2 .001
Mean temperature day 3 (°C) 3 6 . 9 ± 0 . 1 3 7 . 7 ± 0 . 1 <.0001 3 7 . 9 ± 0 . 1 <.0001
Procalcitonin day 1 (ng/mL) 0 . 0 5 ± 0 . 0 1 0 . 2 9 ± 0 . 2 3 NS 0 . 5 3 ± 0 . 0 1 NS<0.5
Procalcitonin day 3 (ng/mL) 0 . 0 5 ± 0 . 0 1 0 . 3 4 ± 0 . 2 4 NS 0 . 6 3 ± 0 . 4 9 .04<0.5
Procalcitonin day 5 (ng/mL) 0 . 0 5 ± 0 . 0 1 0 . 2 0 ± 0 . 0 5 .002 0 . 3 5 ± 0 . 1 0 <.0001<0.5
Interleukin-6 day 1 (pg/mL) 7 . 3 5 ± 1 . 8 1 7 . 0 ± 4 . 1 5 .019 2 1 . 6 ± 7 . 5 .009<6.0
Interleukin-6 day 3 (pg/mL) 9 . 0 ± 1 . 5 2 4 . 2 ± 4 . 0 <.0001 3 6 . 2 5 ± 6 . 8 <.0001<6.0
Interleukin-6 day 5 (pg/mL) 9 . 0 ± 1 . 5 5 3 7 . 4 ± 1 1 . 3 .004 6 4 . 6 ± 2 1 . 5 <.0001<6.0
Lipopolysaccaride-binding protein day 1 (mcg/mL) 1 9 . 0 ± 1 . 6 2 6 . 6 ± 2 . 8 .014 2 9 . 3 ± 4 . 5 .008<8.4
Lipopolysaccaride-binding protein day 3 (mcg/mL) 2 5 . 0 ± 2 . 1 4 4 . 7 ± 6 . 1 .001 5 4 . 3 ± 1 0 . 9 <.0001<8.4
Lipopolysaccaride-binding protein day 5 (mcg/mL) 2 3 . 4 ± 2 . 1 5 0 . 9 ± 6 . 0 <.0001 6 6 . 5 ± 1 0 . 9 <.0001<8.4
C-reactive protein day 1 (mg/L) 1 0 . 2 ± 2 . 0 1 9 . 2 ± 5 . 2 NS 2 2 . 8 ± 7 . 1 .0220–5.0
C-reactive protein day 3 (mg/L) 1 2 . 2 ± 2 . 1 4 6 . 7 ± 9 . 4 5 <.0001 5 8 . 3 ± 1 0 . 2 <.00010–5.0
C-reactive protein day 5 (mg/L) 1 0 . 0 ± 1 . 4 7 8 . 9 ± 1 4 . 0 <.0001 1 1 3 . 7 ± 2 4 . 9 <.00010–5.0
White blood cells day 1 (Gpt/L) 8 . 3 5 ± 0 . 4 1 0 . 3 ± 0 . 5 .006 1 1 . 7 ± 0 . 8 <.00014.0–11.0
White blood cells day 3 (Gpt/L) 8 . 3 ± 0 . 8 1 1 . 9 ± 1 . 7 .034 1 1 . 3 ± 0 . 8 .0344.0–11.0
White blood cells day 5 (Gpt/L) 7 . 4 ± 0 . 6 9 . 6 ± 0 . 5 .01 1 0 . 7 ± 0 . 8 .0064.0–11.0
Monozyte HLA-DR expression day 1 (%) 9 6 . 0 ± 0 . 7 9 2 . 9 ± 1 . 5 .039 9 2 . 1 ± 2 . 4 .034>30
Monozyte HLA-DR expression day 3 (%) 9 5 . 1 ± 1 . 2 8 8 . 1 ± 2 . 1 .002 8 9 . 1 ± 2 . 0 .011>30
Monozyte HLA-DR expression day 5 (%) 9 4 . 2 ± 1 . 3 8 8 . 5 ± 2 . 0 .014 8 5 . 6 ± 3 . 1 .004>30

Data are shown as number for dichotomized variables mean ± standard error of the mean (SEM) for normally distributed continuous variables, or median (range) for abnormally distributed continuous variables. * 𝑃 value for analysis of serious infection versus no infection.