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Stroke Research and Treatment
Volume 2011 (2011), Article ID 858134, 9 pages
doi:10.4061/2011/858134
Preeclampsia and Stroke: Risks during and after Pregnancy
1Department of Neurology, Medical Center Boulevard, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
2Stroke Center Wake Forest University Baptist Medical Center and Women's Health Center of Excellence for Research, Leadership, and Education, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
3Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA
Received 14 October 2010; Accepted 13 December 2010
Academic Editor: Halvor Naess
Copyright © 2011 Cheryl Bushnell and Monique Chireau. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- C. Jaigobin and F. L. Silver, “Stroke and pregnancy,” Stroke, vol. 31, no. 12, pp. 2948–2951, 2000. View at Scopus
- A. H. James, C. D. Bushnell, M. G. Jamison, and E. R. Myers, “Incidence and risk factors for stroke in pregnancy and the puerperium,” Obstetrics and Gynecology, vol. 106, no. 3, pp. 509–516, 2005. View at Scopus
- D. J. Lanska and R. J. Kryscio, “Stroke and intracranial venous thrombosis during pregnancy and puerperium,” Neurology, vol. 51, no. 6, pp. 1622–1628, 1998. View at Scopus
- L. Bellamy, J. P. Casas, A. D. Hingorani, and D. J. Williams, “Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis,” British Medical Journal, vol. 335, no. 7627, pp. 974–977, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. M. Roberts, G. Pearson, J. Cutler, and M. Lindheimer, “Summary of the NHLBI Working Group on research on hypertension during pregnancy,” Hypertension, vol. 41, pp. 437–445, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- B. Sibai, G. Dekker, and M. Kupferminc, “Pre-eclampsia,” The Lancet, vol. 365, no. 9461, pp. 785–799, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- E. A. Steegers, P. von Dadelszen, J. J. Duvekot, and R. Pijnenborg, “Pre-eclampsia,” The Lancet, vol. 376, pp. 631–644, 2010. View at Publisher · View at Google Scholar
- L. Magee, M. Helewa, J.-M. Moutquin, and P. von Dadlszen, “SOGC Guidelines: diagnosis, evaluation, and management of the hypertensive disorders of pregnancy,” Journal of Obstetrics and Gynaecology Canada, vol. 20, supplement, pp. 1–48, 2008.
- M. D. Lindheimer, S. J. Taler, and F. G. Cunningham, “Hypertension in pregnancy,” Journal of the American Society of Hypertension, vol. 4, no. 2, pp. 68–78, 2010. View at Publisher · View at Google Scholar · View at PubMed
- E. J. Roccella, “Report of the National High Blood Pressure Education Program Working Group on high blood pressure in pregnancy,” American Journal of Obstetrics and Gynecology, vol. 183, no. 1, pp. S1–S22, 2000. View at Publisher · View at Google Scholar
- B. M. Sibai, “Chronic hypertension in pregnancy,” Obstetrics and Gynecology, vol. 100, no. 2, pp. 369–377, 2002. View at Publisher · View at Google Scholar
- K. Duckitt and D. Harrington, “Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies,” British Medical Journal, vol. 330, no. 7491, pp. 565–567, 2005. View at Publisher · View at Google Scholar · View at PubMed
- J. I. Einarsson, H. Sangi-Haghpeykar, and M. O. Gardner, “Sperm exposure and development of preeclampsia,” American Journal of Obstetrics and Gynecology, vol. 188, no. 5, pp. 1241–1243, 2003. View at Publisher · View at Google Scholar
- R. T. Lie, S. Rasmussen, H. Brunborg, H. K. Gjessing, E. Lie-Nielsen, and L. M. Irgens, “Fetal and maternal contributions to risk of pre-eclampsia: population based study,” British Medical Journal, vol. 316, no. 7141, pp. 1343–1347, 1998.
- J. M. Roberts and C. A. Hubel, “The two-stage theory of preeclampsia: variations on the theme,” Placenta, vol. 30, supplement A, pp. S32–S37, 2009. View at Publisher · View at Google Scholar · View at PubMed
- R. Skjærven, L. J. Vatten, A. J. Wilcox, T. Rønning, L. M. Irgens, and R. T. Lie, “Recurrence of pre-eclampsia across generations: exploring fetal and maternal genetic components in a population based cohort,” British Medical Journal, vol. 331, no. 7521, pp. 877–879, 2005. View at Publisher · View at Google Scholar · View at PubMed
- K. L. Adeney and M. A. Williams, “Migraine headaches and preeclampsia: an epidemiologic review,” Headache, vol. 46, no. 5, pp. 794–803, 2006. View at Publisher · View at Google Scholar · View at PubMed
- C. D. Bushnell, M. Jamison, and A. H. James, “Migraines during pregnancy linked to stroke and vascular diseases: US population based case-control study,” British Medical Journal, vol. 338, p. b664, 2009. View at Publisher · View at Google Scholar
- S. E. Sanchez, C. Qiu, M. A. Williams, N. Lam, and T. K. Sorensen, “Headaches and migraines are associated with an increased risk of preeclampsia in Peruvian women,” American Journal of Hypertension, vol. 21, no. 3, pp. 360–364, 2008. View at Publisher · View at Google Scholar · View at PubMed
- G. E. Tietjen, M. M. Al-Qasmi, K. Athanas, R. M. Dafer, and S. A. Khuder, “Increased von Willebrand factor in migraine,” Neurology, vol. 57, no. 2, pp. 334–336, 2001.
- T. Sharshar, C. Lamy, and J. L. Mas, “Incidence and causes of strokes associated with pregnancy and puerperium: a study in public hospitals of Ile de France,” Stroke, vol. 26, no. 6, pp. 930–936, 1995.
- J. S. Jeng, S. C. Tang, and P. K. Yip, “Stroke in women of reproductive age: comparison between stroke related and unrelated to pregnancy,” Journal of the Neurological Sciences, vol. 221, no. 1-2, pp. 25–29, 2004. View at Publisher · View at Google Scholar · View at PubMed
- B. T. Bateman, H. C. Schumacher, C. D. Bushnell et al., “Intracerebral hemorrhage in pregnancy: frequency, risk factors, and outcome,” Neurology, vol. 67, no. 3, pp. 424–429, 2006. View at Publisher · View at Google Scholar · View at PubMed
- J. N. Martin, B. D. Thigpen, R. C. Moore, C. H. Rose, J. Cushman, and W. May, “Stroke and severe preeclampsia and eclampsia: a paradigm shift focusing on systolic blood pressure,” Obstetrics and Gynecology, vol. 105, no. 2, pp. 246–254, 2005. View at Publisher · View at Google Scholar · View at PubMed
- J. Hinchey, C. Chaves, B. Appignani et al., “A reversible posterior leukoencephalopathy syndrome,” New England Journal of Medicine, vol. 334, no. 8, pp. 494–500, 1996. View at Publisher · View at Google Scholar
- V. H. Lee, E. F. M. Wijdicks, E. M. Manno, and A. A. Rabinstein, “Clinical spectrum of reversible posterior leukoencephalopathy syndrome,” Archives of Neurology, vol. 65, no. 2, pp. 205–210, 2008. View at Publisher · View at Google Scholar · View at PubMed
- R. B. Schwartz, S. K. Feske, J. F. Polak et al., “Preeclampsia-eclampsia: clinical and neuroradiographic correlates and insights into the pathogenesis of hypertensive encephalopathy,” Radiology, vol. 217, no. 2, pp. 371–376, 2000.
- G. G. Zeeman, “Neurologic complications of pre-eclampsia,” Seminars in Perinatology, vol. 33, no. 3, pp. 166–172, 2009. View at Publisher · View at Google Scholar · View at PubMed
- L. H. Calabrese, D. W. Dodick, T. J. Schwedt, and A. B. Singhal, “Narrative review: reversible cerebral vasoconstriction syndromes,” Annals of Internal Medicine, vol. 146, no. 1, pp. 34–44, 2007.
- S. Koch, A. Rabinstein, S. Falcone, and A. Forteza, “Diffusion-weighted imaging shows cytotoxic and vasogenic edema in eclampsia,” American Journal of Neuroradiology, vol. 22, no. 6, pp. 1068–1070, 2001.
- R. A. Hajj-Ali, A. Furlan, A. Abou-Chebel, and L. H. Calabrese, “Benign angiopathy of the central nervous system: cohort of 16 patients with clinical course and long-term followup,” Arthritis Care and Research, vol. 47, no. 6, pp. 662–669, 2002.
- A. B. Singhal, “Postpartum angiopathy with reversible posterior leukoencephalopathy,” Archives of Neurology, vol. 61, no. 3, pp. 411–416, 2004. View at Publisher · View at Google Scholar · View at PubMed
- S. Riskin-Mashiah, M. A. Belfort, G. R. Saade, and J. A. Herd, “Cerebrovascular reactivity in normal pregnancy and preeclampsia,” Obstetrics and Gynecology, vol. 98, no. 5, pp. 827–832, 2001. View at Publisher · View at Google Scholar
- M. A. Belfort, M. W. Varner, D. S. Dizon-Townson, C. Grunewald, and H. Nisell, “Cerebral perfusion pressure, and not cerebral blood flow, may be the critical determinant of intracranial injury in preeclampsia: a new hypothesis,” American Journal of Obstetrics and Gynecology, vol. 187, no. 3, pp. 626–634, 2002. View at Publisher · View at Google Scholar
- J. L. James, G. S. Whitley, and J. E. Cartwright, “Pre-eclampsia: fitting together the placental, immune and cardiovascular pieces,” Journal of Pathology, vol. 221, no. 4, pp. 363–378, 2010. View at Publisher · View at Google Scholar · View at PubMed
- A. Hawfield and B. I. Freedman, “Pre-eclampsia: the pivotal role of the placenta in its pathophysiology and markers for early detection,” Therapeutic Advances in Cardiovascular Disease, vol. 3, no. 1, pp. 65–73, 2009. View at Publisher · View at Google Scholar · View at PubMed
- V. Shenoy, K. Kanasaki, and R. Kalluri, “Pre-eclampsia: connecting angiogenic and metabolic pathways,” Trends in Endocrinology and Metabolism, vol. 21, pp. 529–536, 2010. View at Publisher · View at Google Scholar · View at PubMed
- S. Venkatesha, M. Toporsian, C. Lam et al., “Soluble endoglin contributes to the pathogenesis of preeclampsia,” Nature Medicine, vol. 12, no. 6, pp. 642–649, 2006. View at Publisher · View at Google Scholar · View at PubMed
- R. J. Levine, C. Lam, C. Qian et al., “Soluble endoglin and other circulating antiangiogenic factors in preeclampsia,” New England Journal of Medicine, vol. 355, no. 10, pp. 992–1005, 2006. View at Publisher · View at Google Scholar · View at PubMed
- G. C. S. Smith, J. P. Pell, and D. Walsh, “Pregnancy complications and maternal risk of ischaemic heart disease: a retrospective cohort study of 129 290 births,” The Lancet, vol. 357, no. 9273, pp. 2002–2006, 2001. View at Publisher · View at Google Scholar · View at PubMed
- D. W. Brown, N. Dueker, D. J. Jamieson et al., “Preeclampsia and the risk of ischemic stroke among young women: results from the stroke prevention in young women study,” Stroke, vol. 37, no. 4, pp. 1055–1059, 2006. View at Publisher · View at Google Scholar · View at PubMed
- M. V. Chireau, C. Bushnell, H. Brown, L. B. Goldstein, and L. A. Bastian, “Pregnancy complications are associated with stroke risk later in life,” Annals of Neurology, vol. 58, supplement 9, p. S41, 2005.
- B. J. Wilson, M. S. Watson, G. J. Prescott et al., “Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study,” British Medical Journal, vol. 326, no. 7394, pp. 845–849, 2003.
- H. U. Irgens, L. Reisæter, L. M. Irgens, and R. T. Lie, “Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study,” British Medical Journal, vol. 323, no. 7323, pp. 1213–1217, 2001.
- R. J. Kaaja and I. A. Greer, “Manifestations of chronic disease during pregnancy,” Journal of the American Medical Association, vol. 294, no. 21, pp. 2751–2757, 2005. View at Publisher · View at Google Scholar · View at PubMed
- L. S. Jonsdottir, R. Arngrimsson, R. T. Geirsson, H. Sigvaldason, and N. Sigfusson, “Death rates from ischemic heart disease in women with a history of hypertension in pregnancy,” Acta Obstetricia et Gynecologica Scandinavica, vol. 74, no. 10, pp. 772–776, 1995.
- J. G. Ray, M. J. Vermeulen, M. J. Schull, and D. A. Redelmeier, “Cardiovascular health after maternal placental syndromes (CHAMPS): population-based retrospective cohort study,” The Lancet, vol. 366, no. 9499, pp. 1797–1803, 2005. View at Publisher · View at Google Scholar · View at PubMed
- P. Hannaford, S. Ferry, and S. Hirsch, “Cardiovascular sequelae of toxaemia of pregnancy,” Heart, vol. 77, no. 2, pp. 154–158, 1997.
- E. Kajantie, J. G. Eriksson, C. Osmond, K. Thornburg, and D. J. P. Barker, “Pre-eclampsia is associated with increased risk of stroke in the adult offspring the helsinki birth cohort study,” Stroke, vol. 40, no. 4, pp. 1176–1180, 2009. View at Publisher · View at Google Scholar · View at PubMed
- N. Sattar, J. Ramsay, L. Crawford, H. Cheyne, and I. A. Greer, “Classic and novel risk factor parameters in women with a history of preeclampsia,” Hypertension, vol. 42, no. 1, pp. 39–42, 2003. View at Publisher · View at Google Scholar · View at PubMed
- H. Laivuori, M. J. Tikkanen, and O. Ylikorkala, “Hyperinsulinemia 17 years after preeclamptic first pregnancy,” Journal of Clinical Endocrinology and Metabolism, vol. 81, no. 8, pp. 2908–2911, 1996. View at Publisher · View at Google Scholar
- M. Vickers, I. Ford, R. Morrison et al., “Markers of endothelial activation and atherothrombosis in women with history of preeclampsia or gestational hypertension,” Thrombosis and Haemostasis, vol. 90, no. 6, pp. 1192–1197, 2003.
- J. C. Chambers, L. Fusi, I. S. Malik, D. O. Haskard, M. De Swiet, and J. S. Kooner, “Association of maternal endothelial dysfunction with preeclampsia,” Journal of the American Medical Association, vol. 285, no. 12, pp. 1607–1612, 2001.
- P. K. Agatisa, R. B. Ness, J. M. Roberts, J. P. Costantino, L. H. Kuller, and M. K. McLaughlin, “Impairment of endothelial function in women with a history of preeclampsia: an indicator of cardiovascular risk,” American Journal of Physiology, vol. 286, no. 4, pp. H1389–H1393, 2004. View at Publisher · View at Google Scholar · View at PubMed
- J. Blaauw, R. Graaff, M. G. Van Pampus et al., “Abnormal endothelium-dependent microvascular reactivity in recently preeclamptic women,” Obstetrics and Gynecology, vol. 105, no. 3, pp. 626–632, 2005. View at Publisher · View at Google Scholar · View at PubMed
- E. G. H. J. Martens, L. L. H. Peeters, E. D. Gommer et al., “The visually-evoked cerebral blood flow response in women with a recent history of preeclampsia and/or eclampsia,” Ultrasound in Medicine and Biology, vol. 35, no. 1, pp. 1–7, 2009. View at Publisher · View at Google Scholar · View at PubMed
- W. Hermes, A. Franx, M. G. van Pampus et al., “10-Year cardiovascular event risks for women who experienced hypertensive disorders in late pregnancy: the HyRAS study,” BMC Pregnancy and Childbirth, vol. 10, article 28, 2010. View at Publisher · View at Google Scholar · View at PubMed
- E. Bujold, S. Roberge, Y. Lacasse et al., “Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis,” Obstetrics and Gynecology, vol. 116, no. 2 PART 1, pp. 402–414, 2010. View at Publisher · View at Google Scholar · View at PubMed
- L. M. Bodnar, J. M. Catov, H. N. Simhan, M. F. Holick, R. W. Powers, and J. M. Roberts, “Maternal vitamin D deficiency increases the risk of preeclampsia,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 9, pp. 3517–3522, 2007. View at Publisher · View at Google Scholar · View at PubMed
- H. Barrett and A. McElduff, “Vitamin D and pregnancy: an old problem revisited,” Best Practice & Research Clinical Endocrinology & Metabolism, vol. 24, pp. 527–539, 2010.
- J. L. Anderson, H. T. May, B. D. Horne et al., “Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population,” American Journal of Cardiology, vol. 106, no. 7, pp. 963–968, 2010. View at Publisher · View at Google Scholar · View at PubMed