Glibenclamide Administration Attenuates Infarct Volume, Hemispheric Swelling, and Functional Impairments following Permanent Focal Cerebral Ischemia in Rats
Figure 1
Glib reduces infarct volume. (a) TTC-stained coronal sections from representative animals given either vehicle or Glib, in brains harvested 48 h after occlusion. Infarcts are shown as pale (unstained) regions involving the striatum and overlying cortex. The infarct area in Glib-treated animals is substantially reduced. (b) Infarct volumes after 48 h of occlusion. Compared to vehicle alone, Glib significantly reduced hemispheric infarct volumes (% of contralateral structure). The data are represented as mean ± SE; P < 0.05; *significant difference compared to MCAO + Vehicle.
