Research Article

Glibenclamide Administration Attenuates Infarct Volume, Hemispheric Swelling, and Functional Impairments following Permanent Focal Cerebral Ischemia in Rats

Table 1

Physiological variables: Using a SurgiVet pulse oximeter, blood SPO2 was monitored and maintained at levels greater than or equal to 90%. Body temperature was monitored throughout surgery by rectal probe and maintained at 37°C using a homeothermic heat lamp temperature controller.

Weight% occlusionGlucoseHb

Sham ( 𝑛 = 7 ) 3 3 0 . 2 8 ± 1 4 . 3 7 2 0 3 . 8 5 ± 1 9 . 5 4 1 4 . 7 ± 0 . 7 2
pMCAO ( 𝑛 = 8 ) 3 3 2 . 8 7 ± 1 3 . 8 5 7 8 . 4 5 ± 5 . 1 9 1 9 2 . 1 3 ± 2 1 . 8 4 1 5 . 1 4 ± 0 . 5 2
pMCAO + Glib ( 𝑛 = 7 ) 3 2 6 . 8 5 ± 1 8 . 0 8 7 6 . 8 3 ± 3 . 6 4 2 0 5 . 1 4 ± 2 9 . 1 3 1 5 . 1 1 ± 1 . 0 8