Clinical Study
Intravenous Thrombolytic Treatment in the Oldest Old
Table 1
Baseline characteristics and aetiology.
| | <85 years old | Oldest Old | Group comparison
value |
| | n (%) | 1399 (93) | 106 (7) | | | Age, y-o (median, range) | 71 (18–84) | 88 (85–101) | | | Gender | | | | | Female, (%) | 630 (45.1) | 73 (69.9) | < 0.001 | | Risk factors | | | | | Arterial hypertension, (%) | 837 (60.4) | 81 (78.6) | <0.001 | | Diabetes mellitus, (%) | 280 (20.2) | 14 (13.6) | 0.103 | | Dyslipemia, (%) | 485 (35.2) | 29 (28.2) | 0.149 | | Current smoking, (%) | 322 (23.3) | 1 (1) | < 0.001 | | Atrial fibrillation, (%) | 241 (17.4) | 31 (30.1) | 0.001 | | Prior antiplatelet therapy, (%) | 280 (20.2) | 34 (33) | 0.002 | | Prior anticoagulation therapy, (%) | 57 (4.1) | 7 (6.8) | 0.149 | | Elevated BP (>185/110 mg Hg) on admission n (%) | 200 (14.8) | 27 (26.7) | 0.001 | | Blood glucose on admission (mmol/dL), median (IQR) | 119 (102–144) | 118 (10.5–151.5) | 0.415 | | Baseline NIHSS, median (IQR) | 13 (8–18) | 16 (10–21) | < 0.001 | | Time (min), median (IQR) | | | | | Stroke onset-to-door time | 75 (55–110) | 85 (64–115) | 0.049 | | Door-to-treatment time | 58 (42–76) | 58 (45–74) | 0.808 | | Stroke onset-to-treatment time | 144.5 (115–173.7) | 142.5 (120–186.2) | 0.265 | | Aetiology, (%) | | | | | Atherothrombotic | 325 (24.2) | 19 (20.2) | ns | | Cardioembolic | 565 (42.1) | 58 (61.7) | 0.025 | | Lacunar | 60 (4.5) | 1 (1.1) | ns | | Other determined aetiology | 72 (5.4) | 0 | ns | | Undetermined aetiology | 321 (23.9) | 16 (17) | ns |
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NIHSS: National Institutes of Health Stroke Scale; IQR: interquartile range; BP: blood pressure. Statistical significance .
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