Review Article
Clinical Trials in Cardiac Arrest and Subarachnoid Hemorrhage: Lessons from the Past and Ideas for the Future
Table 5
Number of randomized, controlled trials published and ongoing for aneurysmal subarachnoid hemorrhage and cardiac arrest.
| Intervention | SAH | Cardiac arrest | Published (%) | Ongoing (%) | Published (%) | Ongoing (%) |
| Calcium channel blockers | 10 (18) | 0 | 4 (9) | 0 | Antifibrinolytics | 5 (9) | 0 | 0 | 0 | Neuroprotective drugs | 5 (9) | 2 (8) | 1 (2) | 1 (7) | Statins | 4 (7) | 5 (20) | 0 | 0 | Aneurysm clip or coil | 4 (7) | 1 (4) | NA | NA | Lipid peroxidation inhibitor | 4 (7) | 1 (4) | 0 | 0 | Thrombolytics | 3 (5) | 1 (4) | 2 (4) | 0 | Antiplatelets | 3 (5) | 0 | 0 | 0 | Steroids | 3 (5) | 0 | 1 (2) | 0 | Transfusion/blood products/erythropoietin | 3 (5) | 1 (4) | 0 | 0 | Vasodilators | 3 (5) | 4 (16) | 0 | 0 | Pressors or HHH | 2 (4) | 2 (8) | 9 (19.5) | 0 | Magnesium | 2 (4) | 0 | 5 (11) | 1 (7) | Rho-kinase inhibitor (fasudil) | 2 (4) | 0 | 0 | 0 | Adrenergic blockade | 1 (2) | 0 | 0 | 0 | Endovascular therapy | 1 (2) | 0 | NA | NA | Insulin/glucose control | 1 (2) | 0 | 2 (4) | 0 | Hypothermia | 1 (2) | 0 | 5 (11) | 9 (64) | CSF diversion | 0 | 2 (8) | 0 | 0 | Antiepileptics | 0 | 2 (8) | 0 | 0 | Sedation | 0 | 1 (4) | 0 | 0 | Rehabilitation | 0 | 1 (4) | 0 | 0 | Blood pressure | 0 | 1 (4) | 0 | 0 | Other | 0 | 1 (4) | 0 | 0 | Chest compressions | NA | NA | 7 (15) | 2 (14) | Adenosine antagonist | 0 | 0 | 1 (2) | 0 | Fluid management | 0 | 0 | 1 (2) | 0 | Barbiturate | 0 | 0 | 1 (2) | 0 | Cerebral oxygenation | 0 | 0 | 0 | 1 (7) | Calcium chloride | 0 | 0 | 3 (7) | 0 | Sodium bicarbonate | 0 | 0 | 2 (4) | 0 | Hemofiltration | 0 | 0 | 1 (2) | 0 | Rhythm analysis | 0 | 0 | 1 (2) | 0 |
| Total | 57 | 25 | 46 | 14 |
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