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Stroke Research and Treatment
Volume 2013 (2013), Article ID 425281, 9 pages
http://dx.doi.org/10.1155/2013/425281
Review Article

Acute Microvascular Changes after Subarachnoid Hemorrhage and Transient Global Cerebral Ischemia

Division of Neurosurgery, St. Michael's Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Department of Surgery, University of Toronto, Toronto, ON, Canada M5B 1W8

Received 9 January 2013; Revised 26 February 2013; Accepted 28 February 2013

Academic Editor: Fatima A. Sehba

Copyright © 2013 Michael K. Tso and R. Loch Macdonald. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Subarachnoid hemorrhage and transient global cerebral ischemia result in similar pathophysiological changes in the cerebral microcirculation. These changes include microvascular constriction, increased leukocyte-endothelial interactions, blood brain barrier disruption, and microthrombus formation. This paper will look at various animal and preclinical studies that investigate these various microvascular changes, perhaps providing insight in how these microvessels can be a therapeutic target in both subarachnoid hemorrhage and transient global cerebral ischemia.