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Stroke Research and Treatment
Volume 2013 (2013), Article ID 539146, 8 pages
http://dx.doi.org/10.1155/2013/539146
Clinical Study

Combining rTMS and Task-Oriented Training in the Rehabilitation of the Arm after Stroke: A Pilot Randomized Controlled Trial

1Division of Experimental Medicine, McGill University, 1110 Pine Avenue West, Montreal, QC, Canada
2School of Rehabilitation, Faculty of Medicine, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montreal, QC, Canada H3C 3J7
3Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR), 2275, Avenue Laurier Est, Montréal, QC, Canada H2H 2N8
4Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687, Pine Avenue West, Montreal, QC, Canada H3A 1A1
5Division of Geriatrics, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, Montreal, QC, Canada H3A 1A1
6The Allan Memorial Institute, P2.142, McGill University Health Centre, 1025 Pine Avenue West, Montreal, QC, Canada H3A 1A1
7Department of Neurology, Affiliated Foshan Hospital of Sun Yat-sen University, Foshan, Guangdong, China

Received 15 July 2013; Accepted 22 September 2013

Academic Editor: Alexander C. H. Geurts

Copyright © 2013 Johanne Higgins et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Kwakkel, R. C. Wagenaar, T. W. Koelman, G. J. Lankhorst, and J. C. Koetsier, “Effects of intensity of rehabilitation after stroke: a research synthesis,” Stroke, vol. 28, no. 8, pp. 1550–1556, 1997. View at Scopus
  2. P. Langhorne, R. Wagenaar, and C. Partridge, “Physiotherapy after stroke: more is better?” Physiotherapy Research International, vol. 1, no. 2, pp. 75–88, 1996. View at Scopus
  3. C. G. Mansur, F. Fregni, P. S. Boggio et al., “A sham stimulation-controlled trial of rTMS of the unaffected hemisphere in stroke patients,” Neurology, vol. 64, no. 10, pp. 1802–1804, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Takeuchi, T. Chuma, Y. Matsuo, I. Watanabe, and K. Ikoma, “Repetitive transcranial magnetic stimulation of contralesional primary motor cortex improves hand function after stroke,” Stroke, vol. 36, no. 12, pp. 2681–2686, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. F. Fregni, P. S. Boggio, A. C. Valle et al., “A sham-controlled trial of a 5-day course of repetitive transcranial magnetic stimulation of the unaffected hemisphere in stroke patients,” Stroke, vol. 37, no. 8, pp. 2115–2122, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. E. M. Khedr, M. A. Ahmed, N. Fathy, and J. C. Rothwell, “Therapeutic trial of repetitive transcranial magnetic stimulation after acute ischemic stroke,” Neurology, vol. 65, no. 3, pp. 466–468, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. Y.-H. Kim, S. H. You, M.-H. Ko et al., “Repetitive transcranial magnetic stimulation-induced corticomotor excitability and associated motor skill acquisition in chronic stroke,” Stroke, vol. 37, no. 6, pp. 1471–1476, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. E. M. Khedr, M. R. Abdel-Fadeil, A. Farghali, and M. Qaid, “Role of 1 and 3 Hz repetitive transcranial magnetic stimulation on motor function recovery after acute ischaemic stroke,” European Journal of Neurology, vol. 16, no. 12, pp. 1323–1330, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. E. M. Khedr, A. E. Etraby, M. Hemeda, A. M. Nasef, and A. A. E. Razek, “Long-term effect of repetitive transcranial magnetic stimulation on motor function recovery after acute ischemic stroke,” Acta Neurologica Scandinavica, vol. 121, no. 1, pp. 30–37, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. M. P. Malcolm, W. J. Triggs, K. E. Light et al., “Repetitive transcranial magnetic stimulation as an adjunct to constraint-induced therapy: an exploratory randomized controlled trial,” American Journal of Physical Medicine and Rehabilitation, vol. 86, no. 9, pp. 707–715, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Richards, L. J. G. Rothi, S. Davis, S. S. Wu, and S. E. Nadeau, “Limited dose response to Constraint-Induced Movement Therapy in patients with chronic stroke,” Clinical Rehabilitation, vol. 20, no. 12, pp. 1066–1074, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Talelli, A. Wallace, M. Dileone, et al., “Theta burst stimulation in the rehabilitation of the upper limb: a semirandomized, placebo- controlled trial in chronic stroke patients,” Neurorehabilitation and Neural Repair, vol. 26, no. 8, pp. 976–987, 2012.
  13. P. Talelli, R. J. Greenwood, and J. C. Rothwell, “Exploring Theta Burst Stimulation as an intervention to improve motor recovery in chronic stroke,” Clinical Neurophysiology, vol. 118, no. 2, pp. 333–342, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. P. B. Fitzgerald, T. L. Brown, Z. J. Daskalakis, R. Chen, and J. Kulkarni, “Intensity-dependent effects of 1 Hz rTMS on human corticospinal excitability,” Clinical Neurophysiology, vol. 113, no. 7, pp. 1136–1141, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. P. B. Fitzgerald, S. Fountain, and Z. J. Daskalakis, “A comprehensive review of the effects of rTMS on motor cortical excitability and inhibition,” Clinical Neurophysiology, vol. 117, no. 12, pp. 2584–2596, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Lang, J. Harms, T. Weyh et al., “Stimulus intensity and coil characteristics influence the efficacy of rTMS to suppress cortical excitability,” Clinical Neurophysiology, vol. 117, no. 10, pp. 2292–2301, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. S. H. Lisanby, D. Gutman, B. Luber, C. Schroeder, and H. A. Sackeim, “Sham TMS: intracerebral measurement of the induced electrical field and the induction of motor-evoked potentials,” Biological Psychiatry, vol. 49, no. 5, pp. 460–463, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. F. S. Cromwell, Occupational Therapist's Manual for Basic Skill Assessment; Primary Prevocational Evaluation, Fair Oaks, Pasadena, Calif, USA, 1965.
  19. J. Desrosiers, G. Bravo, R. Hebert, E. Dutil, and L. Mercier, “Validation of the Box and Block Test as a measure of dexterity of elderly people: reliability, validity, and norms studies,” Archives of Physical Medicine and Rehabilitation, vol. 75, no. 7, pp. 751–755, 1994. View at Scopus
  20. V. Mathiowetz, G. Volland, N. Kashman, and K. Weber, “Adult norms for the box and block test of manual dexterity,” The American Journal of Occupational Therapy, vol. 39, no. 6, pp. 386–391, 1985. View at Scopus
  21. D. M. Morris, G. Uswatte, J. E. Crago, E. W. Cook III, and E. Taub, “The reliability of the wolf motor function test for assessing upper extremity function after stroke,” Archives of Physical Medicine and Rehabilitation, vol. 82, no. 6, pp. 750–755, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. S. L. Wolf, P. A. Catlin, M. Ellis, A. L. Archer, B. Morgan, and A. Piacentino, “Assessing wolf motor function test as outcome measure for research in patients after stroke,” Stroke, vol. 32, no. 7, pp. 1635–1639, 2001. View at Scopus
  23. S. L. Wolf, P. A. Thompson, D. M. Morris et al., “The EXCITE trial: attributes of the wolf motor function test in patients with subacute stroke,” Neurorehabilitation and Neural Repair, vol. 19, no. 3, pp. 194–205, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Uswatte, E. Taub, D. Morris, M. Vignolo, and K. McCulloch, “Reliability and validity of the upper-extremity motor activity log-14 for measuring real-world arm use,” Stroke, vol. 36, no. 11, pp. 2493–2496, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. V. Mathiowetz, K. Weber, G. Volland, and N. Kashman, “Reliability and validity of grip and pinch strength evaluations,” Journal of Hand Surgery, vol. 9, no. 2, pp. 222–226, 1984. View at Scopus
  26. P. W. Duncan, S. M. Lai, R. K. Bode, S. Perera, and J. DeRosa, “Stroke impact scale-16: a brief assessment of physical function,” Neurology, vol. 60, no. 2, pp. 291–296, 2003. View at Scopus
  27. J. P. Brasil-Neto, L. G. Cohen, M. Panizza, J. Nilsson, B. J. Roth, and M. Hallett, “Optimal focal transcranial magnetic activation of the human motor cortex: effects of coil orientation, shape of the induced current pulse, and stimulus intensity,” Journal of Clinical Neurophysiology, vol. 9, no. 1, pp. 132–136, 1992. View at Scopus
  28. P. M. Rossini, A. T. Barker, A. Berardelli et al., “Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee,” Electroencephalography and Clinical Neurophysiology, vol. 91, no. 2, pp. 79–92, 1994. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Gowland, P. Stratford, M. Ward et al., “Measuring physical impairment and disability with the Chedoke-McMaster Stroke Assessment,” Stroke, vol. 24, no. 1, pp. 58–63, 1993. View at Scopus
  30. K. F. Schulz, D. G. Altman, and D. Moher, “CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials,” Annals of Internal Medicine, vol. 152, no. 11, pp. 726–732, 2010. View at Scopus
  31. R. Iqbal, A. Haroon, A. Jabbar, N. Babar, and R. Qureshi, “What method of contact works best for recruiting participants in a study: lessons for health care researchers?” Journal of Pakistan Medical Association, vol. 62, pp. 1293–1297, 2012.
  32. J. Seniow, M. Bilik, M. Lesniak, K. Waldowski, S. Iwanski, and A. Czlonkowska, “Transcranial magnetic stimulation combined with physiotherapy in rehabilitation of poststroke hemiparesis: a randomized, double-blind, placebo-controlled study,” Neurorehabilitation and Neural Repair, vol. 26, no. 9, pp. 1072–1079, 2012.
  33. A. Avenanti, M. Coccia, E. Ladavas, L. Provinciali, and M. G. Ceravolo, “Low- frequency rTMS promotes use-dependent motor plasticity in chronic stroke: a randomized trial,” Neurology, vol. 78, no. 4, pp. 256–264, 2012.
  34. A. B. Conforto, S. M. Anjos, G. Saposnik, et al., “Transcranial magnetic stimulation in mild to severe hemiparesis early after stroke: a proof of principle and novel approach to improve motor function,” Journal of Neurology, vol. 259, no. 7, pp. 1399–1405, 2012.
  35. F. Maeda, J. P. Keenan, J. M. Tormos, H. Topka, and A. Pascual-Leone, “Interindividual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability,” Experimental Brain Research, vol. 133, no. 4, pp. 425–430, 2000. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Gangitano, A. Valero-Cabré, J. M. Tormos, F. M. Mottaghy, J. R. Romero, and Á. Pascual-Leone, “Modulation of input-output curves by low and high frequency repetitive transcranial magnetic stimulation of the motor cortex,” Clinical Neurophysiology, vol. 113, no. 8, pp. 1249–1257, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. B. O. Adeyemo, M. Simis, D. D. Macea, and F. Fregni, “Systematic review of parameters of stimulation, clinical trial design characteristics, and motor outcomes in non-invasive brain stimulation in stroke,” Frontiers in Psychiatry, vol. 3, pp. 1–27, 2012.