Research Article
CSF and Serum Biomarkers Focusing on Cerebral Vasospasm and Ischemia after Subarachnoid Hemorrhage
Table 1
Summary of the literature focusing on S100B and NSE as biomarkers after SAH predictive of CVS and/or DCI.
| Author | Year | Serum biomarker | Sample collection | CVS assessment | CVS | DCI assessment | DCI | Bad outcome |
| Herrmann et al. [20] | 2000 | S100B | First 4 days after ischemic stroke | NE | NE | CT | ++ | ++ | | | No NSE detection | | | NE | for ischemia detection | (volume of lesion) | |
| Oertel et al. [21] | 2006 | S100B | First 3 days after SAH | TCD | | NE | NE | | | | NSE | | | | NE | NE | |
| Weiss et al. [22] | 2006 | S100B | First 8 days after SAH | TCD + arteriography | − | NE | NE | ++ | | | No NSE detection | | |
(only CVS + S100B < 0.4 g/L: no death) | | |
| Sanchez-Pea et al. [23] | 2008 | S100B | First 15 days after SAH | TCD + arteriography | in “ischemic vasospasm” patients | ++ () | | | No NSE detection | | | | | | (only mean 15 day S100B value) |
| Moritz et al. [24] | 2010 | S100B | Daily during ICU stay | TCD | − | CT | ++ | ++ | | | NSE | | | − | CT | + | + (only NSE peak value) |
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NE: not evaluated; ↑: increase; ↓: decrease; “−”: no correlation; “+”: positive correlation; “++”: prognostic factor; TCD: transcranial doppler sonography;
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