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Stroke Research and Treatment
Volume 2013 (2013), Article ID 615154, 13 pages
http://dx.doi.org/10.1155/2013/615154
Review Article

Aneurysmal Subarachnoid Hemorrhage Models: Do They Need a Fix?

1Departments of Neurosurgery and Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
2Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA

Received 15 April 2013; Revised 31 May 2013; Accepted 4 June 2013

Academic Editor: R. Loch Macdonald

Copyright © 2013 Fatima A. Sehba and Ryszard M. Pluta. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The discovery of tissue plasminogen activator to treat acute stroke is a success story of research on preventing brain injury following transient cerebral ischemia (TGI). That this discovery depended upon development of embolic animal model reiterates that proper stroke modeling is the key to develop new treatments. In contrast to TGI, despite extensive research, prevention or treatment of brain injury following aneurysmal subarachnoid hemorrhage (aSAH) has not been achieved. A lack of adequate aSAH disease model may have contributed to this failure. TGI is an important component of aSAH and shares mechanism of injury with it. We hypothesized that modifying aSAH model using experience acquired from TGI modeling may facilitate development of treatment for aSAH and its complications. This review focuses on similarities and dissimilarities between TGI and aSAH, discusses the existing TGI and aSAH animal models, and presents a modified aSAH model which effectively mimics the disease and has a potential of becoming a better resource for studying the brain injury mechanisms and developing a treatment.