Hypoxic-Ischemic Neonatal Encephalopathy: Animal Experiments for Neuroprotective Therapies

Figure 1

The Levine-Rice model of 7-day-old Wistar rat (from left to right). Under ether anesthesia, skin was incised, and unilateral common carotid artery was doubly ligated. After recovery, they were transferred to a chamber containing humidified 8% hypoxic gas. Brain was removed for histological study. The ligated side of the hemisphere was atrophic.