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Stroke Research and Treatment
Volume 2013 (2013), Article ID 948783, 7 pages
http://dx.doi.org/10.1155/2013/948783
Research Article

The Impact of Experimental Preconditioning Using Vascular Endothelial Growth Factor in Stroke and Subarachnoid Hemorrhage

1Department of Neurosurgery, Heinrich-Heine-University, Medical Faculty, 40225 Düsseldorf, Germany
2Department of Neurosurgery, University Medical Center, Hamburg-Eppendorf, 20246 Hamburg, Germany
3Department of Radiology, Heinrich-Heine-University, Medical Faculty, 40225 Düsseldorf, Germany

Received 13 November 2012; Accepted 28 February 2013

Academic Editor: Fatima A. Sehba

Copyright © 2013 Sven Oliver Eicker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Vascular endothelial growth factor (VEGF) stimulating angiogenesis was shown to be a potential novel therapeutic approach for the treatment of ischemic vascular diseases. The goal of the present study was to examine whether transfection of VEGF before occurrence of major stroke (part I) and cerebral vasospasm after experimental subarachnoid hemorrhage (SAH; part II) develops neuroprotective qualities. A total of 25 (part I) and 26 (part II) brains were analyzed, respectively. In part one, a significant reduction of infarct volume in the VEGF-treated stroke animals (43% reduction, ) could be detected. In part two, significant vasospasm was induced in all hemorrhage groups . Analyzing microperfusion, a significant higher amount of perfused vessels could be detected , whereas no significant effect could be detected towards macroperfusion. Histologically, no infarctions were observed in the VEGF-treated SAH group and the sham-operated group. Minor infarction in terms of vasospasm-induced small lesions could be detected in the control vector transduced group and saline-treated group . The present study demonstrates the preconditioning impact of systemic intramuscular VEGF injection in animals after major stroke and induced severe vasospasm after SAH.