Sex, Diastolic Blood Pressure, and Outcome after Thrombolysis for Ischemic Stroke
Table 1
Baseline characteristics.
Total ()
Men ()
Women ()
value
Age
71 (63–71)
69 (61–76)
76 (67–84)
<0.0001
Medical history
Atrial fibrillation
73 (20.6)
29 (15)
44 (27.2)
0.005
Diabetes
51 (14.4)
23 (11.9)
28 (17.3)
0.2
Smoke currently
77 (21.7)
43 (23.4)
34 (22.5)
0.89
BMI
26 ± 4.4
26 ± 4.0
26 ± 13.0
0.9
Hypertension
168 (47.3)
80 (41.5)
88 (54.3)
0.02
Clinical assessment
Baseline NIHSS score
5 (3–11)
5 (3–9)
7 (3–14)
0.006
Systolic BP, mmHg
152 ± 20
152 ± 20
152 ± 20
0.9
Diastolic BP, mmHg
81 ± 13
84 ± 13
78 ± 12
<0.0001
Diastolic BP >90 mmHg
78 (22)
55 (28.5)
23 (14.2)
0.001
MAP, mmHg
104 ± 13
107 ± 13
102 ± 12
0.002
Laboratory findings
Glucose at admission, mmol/L
7.0 ± 2.4
7.1 ± 2.7
6.8 ± 2.7
0.18
Triglycerides, mmol/L
1.4 ± 0.9
1.4 ± 0.8
1.4 ± 1.0
0.8
LDL-cholesterol, mmol/L
3.1 ± 1.0
3.1 ± 1.0
3.0 ± 0.9
0.4
HDL-cholesterol, mmol/L
1.4 ± 0.4
1.3 ± 0.4
1.5 ± 0.5
0.0001
CRP
6.1 ± 14
5.7 ± 13
6.6 ± 16
0.6
Creatinine clearance, mL/min
76 ± 32
86 ± 32
65 ± 29
<0.0001
Treatment
Statins
82 (23.1)
44 (23.2)
38 (23.8)
0.9
ASA
146 (41.1)
67 (35.3)
79 (49.1)
0.009
Antihypertensive treatment
196 (55.2)
89 (47.6)
107 (66.9)
0.0003
B-blocker
135 (38.0)
57 (30.5)
78 (48.8)
0.001
Diuretics
61 (17.2)
20 (10.8)
41 (25.6)
0.0003
ACE inhibitors
62 (17.5)
37 (19.9)
25 (15.6)
0.3
Angiotensin receptor blockers
30 (8.5)
13 (7.0)
17 (10.6)
0.2
Calcium channel blockers
56 (15.8)
28 (15.1)
28 (17.5)
0.5
Door-needle, minutes
60 (50–77)
60 (51–78)
59 (49–77)
0.8
Abbreviations: BMI: body mass index; BP: blood pressure; NIHSS: National Institute of Health Stroke Scale; IGT: impaired glucose tolerance; MAP: mean arterial pressure; OGTT: oral glucose tolerance test; OGTT-120 min, 120 minutes post glucose challenge during oral glucose tolerance test; mRS: modified rankin scale; CRP: c reactive protein; LDL: low density lipoprotein; HDL: high density lipoprotein; ASA: acetyl salicylic acid. Data are described as (%), means ± SD or median with interquartile range in parentheses. Creatinin-clearance is calculated from the Cockroft-Gault formula.
