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Functional Genomics, Epigenetic Regulation, and Biomarkers in Stroke

Call for Papers

The completion of the human genome project sparked an era of new discovery and investigation in all human diseases including stroke. With advanced technologies, such as next generation sequencing, proteomics, and large clinical registries, now available, we are beginning to uncover the intricate disarrangement of complex pathways that lead to phenotypic changes in stroke. In addition, our understanding of the epigenetic factors that regulate transcription has dramatically changed our understanding of stroke pathology. Furthermore, advancements in genomics, proteomics, and metabolomics have permitted the search for novel biomarkers and therapeutic targets that may lead to new therapeutic approaches.

We invite investigators to contribute original research and review articles that will further our understanding of epigenetic regulation and biomarker discovery in stroke pathology. We are particularly interested in basic, translational, and/or clinical research articles describing the state of functional genomics in the study of epigenetic regulation and biomarker discovery in stroke research. Research on biomarker application including prognostic tools and development of novel therapeutics in stroke is also encouraged.

Potential topics include, but are not limited to:

  • Functional genomics in stroke research (e.g., omic approaches, bioinformatics, and computational systems biology)
  • Mechanisms of epigenetic gene regulation in stroke
  • Noncoding RNA based epigenetic regulation (e.g., long noncoding RNAs, microRNAs, small nucleolar RNA, and Piwi-interacting RNAs)
  • Characterization and function of stroke related noncoding RNAs
  • Therapeutic approaches that target DNA methylation and chromatin remodeling
  • Characterization of genomic, proteomic, and metabolic biomarkers in stroke and/or stroke therapy
Manuscript DueFriday, 19 September 2014
First Round of ReviewsFriday, 12 December 2014
Publication DateFriday, 6 February 2015

Lead Guest Editor

Guest Editors

  • Michael Strong, Tulane University School of Medicine, New Orleans, USA
  • Ricky Medel, Tulane University School of Medicine, New Orleans, USA
  • Robert M. Starke, University of Virginia School of Medicine, Charlottesville, USA