Variability in the Responsiveness to Low-Dose Aspirin: Pharmacological and Disease-Related Mechanisms

<table>Serum TXB<sub>2</sub> production from low-dose aspirin-treated patients with essential thrombocythemia <i>ex vivo</i> and after <i>in vitro</i> incubation of additional aspirin. Box-whisker plots of serum TXB<sub>2</sub> values from 14 patients chronically treated with 100 mg/die aspirin, without (vehicle) and with <i>in vitro</i> incubation with 50 <i>μ</i>M aspirin. *<svg height="11.375" id="M19" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.875 11.375" width="66.875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,15.582,11.112)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,30.286,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,38.446,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,42.321,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,50.481,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,58.64,11.112)"><use xlink:href="#x31"></use></g>
</svg>. This figure is modified from [<a href="/journals/thrombosis/2012/376721/#B67">25</a>].</table>

Thrombosis

fig4

Figure 4

Figure 4: Variability in the Responsiveness to Low-Dose Aspirin: Pharmacological and Disease-Related Mechanisms 