Review Article
Variability in the Responsiveness to Low-Dose Aspirin: Pharmacological and Disease-Related Mechanisms
Table 1
Main pharmacological features of drug resistance versus variability in drug response.
| Resistance | Variability |
| (i) is usually triggered by drug exposure, slowly reversible, and often drug specific | (i) not induced by and often independent of the drug, can affect different drugs, and does not revert upon withdrawal |
| (ii) implies a change of the drug target making it inaccessible or no longer inhibitable | (ii) the drug target is not necessarily modified or inaccessible |
| (iii) detectable by specific laboratory tests, which impact on the clinical decision of changing drug | (iii) laboratory tests are of little help in therapeutic decisions if mechanism(s) are unknown (change drug, increase dose, more frequent intake?) |
|
|