Urinary Prothrombin Fragment 1+2 in relation to Development of Non-Symptomatic and Symptomatic Venous Thromboembolic Events following Total Knee Replacement

Table 3

Levels of prothrombin fragment 1+2 excreted in urine in the VTE and the control groups. Values shown are median (lower limit of detection 20 pmol/L, upper limit 1,200 pmol/L). *Wilcoxon test (two-sided). ^†Day of venography was day 7 ± 2 after surgery. TKR: total knee replacement; VTE: venous thromboembolism.

	Prothrombin fragment 1+2 levels in urine, pmol/L, median (range)
	VTE group (𝑛=142)	Control group (𝑛=140)	𝑃 value*
Day of TKR	20 (<20–1,025)	20.7 (<20–457.5)	.45
Day 1 after TKR	141.0 (<20–>1,200)	71.8 (<20–>1,200)	.0032
Day 3 after TKR	295.9 (<20–>1,200)	130.8 (<20–>1,200)	.0002
Day of venography^†	39.7 (<20–869.1)	30.0 (<20–660.2)	.0083
Follow-up (day 39)	23.0 (<20–>1,200)	20.9 (<20–831.8)	.3445