Research Article

Gender and Vascular Complications in the JAK2 V617F-Positive Myeloproliferative Neoplasms

Table 1

Baseline characteristics in the MPN cohort, by gender.

FemaleMaleP value

Diagnosis, number (%)
 All MPN1641060.001
 ET43 (26)18 (17)
 PV104 (64)57 (54)
 MF17 (10)31 (29)

Age at diagnosis, median (IQR)
 All MPN50 (37–61)56 (48–67)0.001
 ET50 (36–59)48 (31–60)
 PV48 (34–61)56 (50–66)
 MF58 (51–63)61 (51–67)

Disease duration, median (IQR)
 All MPN5 (3–11)5 (1–9)0.04
 ET4 (2–10)3 (1–9)
 PV6 (3–12)4 (1–8)
 MF6 (3–12)6 (2–11)

Hypertension, number (%)2 missing
 All MPN53 (33%)44 (42%)0.15
 ET134
 PV3529
 MF511

Diabetes Mellitus, number (%)1 missing
 All MPN7 (4%)8 (8%)0.28
 ET00
 PV56
 MF22

Dyslipidemia, number (%)
 All MPN15 (9)26 (25)0.001
 ET23
 PV1215
 MF18

Smoking history, number (%)
 All MPN35 (22)40 (39)0.005
 ET124
 PV1725
 MF611

Median white blood cell count, × 109/L (IQR)
 All MPN9.5 (7.3, 14.8)13.2 (8.3, 21.4)0.02
 ET8 (6.8, 9)8.7 (6–10.8)
 PV11.1 (7.5,18.4)13.9 (9.6, 20)
 MF25 (6.9, 49)15.9 (7.9, 26.6)

Median hemoglobin, g/dL; (IQR)
 All MPN12.9 (11.6, 14)13.2 (11.4, 14.4)0.73
 ET13.7 (12.7, 14.2)14.7 (13.2–15.1)
 PV12.8 (11.6, 13.8)13.6 (12.6–14.4)
 MF10.6 (9.9, 12.5)10 (9, 11.8)

Median Platelet count, × 109/L (IQR)
 All MPN527 (333, 678)450 (246–673)0.09
 ET568 (499–782)476 (412–654)
 PV526 (340–667)502 (300–700)
 MF214 (133–330)272 (166, 477)

JAK2 V617F allele burden, median (IQR)
 All MPN53 (42–69)63 (46–83)0.05
 ET34 (22–44)44 (34–48)
 PV64 (50–71)71 (55–88)
 MF82 (55–100)57 (48–77)

JAK2 genotype0.1
 Heterozygous86 (53%)45 (42%)
 Homozygous77 (47%)61 (58%)

Anti-platelet Use, number (%)
 All MPN81 (59)69 (69)0.12
 ET2611
 PV5041
 MF517

Warfarin Use, number (%)
 All MPN17 (10%)7 (7%)0.28
 ET43
 PV134
 MF00

Hydroxyurea Use, number (%)
 All MPN48 (30%)28 (27%)0.58
 ET113
 PV3317
 MF48

Interferon Use, number (%)
 All MPN5 (3%)3 (3%)0.99
 ET01
 PV40
 MF12

Anagrelide Use, number (%)
 All MPN11 (7%)4 (4%)0.42
 ET41
 PV61
 MF12

*7 women with missing data.*4 men with missing data.**27 women with missing data.**6 men with missing data.