Anticoagulant and Antiplatelet Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease

Table 5

U. S. Anticoagulation regimen after stent implantation (adopted from Paikin et al.) [6].

Setting	Anticoagulation/Antiplatelets
CHADS2  0-1	Aspirin + clopidogrel
CHADS2 > 1, low bleeding risk	Aspirin + clopidogrel + warfarin
CHADS2 > 1, high bleeding risk	Aspirin + clopidogrel

CHADS₂: cardiac failure, hypertension, age, diabetes, stroke (doubled). High risk of bleeding: for example, age > 75 year, severe renal dysfunction, recent gastrointestinal bleeding, prior stroke, uncontrolled hypertension. Bare metal stents should be preferred, the duration of triple therapy months should be restricted to 1 month after bare metal stent implantation and 3 after drug eluting stent implantation (6 months in paclitaxel stents).