Table 1: Pharmacokinetic parameters of argatroban in pigs after s.c. administration of 0.5 mg·kg−1 of two different formulations of this inhibitor: sorbitol/ethanol and saline solution. Values are the mean of 𝑛 = 5 , showing the standard deviation. 𝑃 < 0 . 0 5 ; 𝑃 < 0 . 0 1 .

Argatroban formulation
Sorbitol/ethanolSaline solution

𝑡 1 / 2 𝛽 (h) 1 4 . 4 6 ± 3 . 9 1 4 . 3 8 ± 0 . 4 3
𝐶 m a x (μg·mL−1) 1 . 0 7 2 ± 0 . 1 3 2 . 4 8 ± 0 . 5 7
𝑡 m a x (h) 3 . 8 0 ± 1 . 3 0 0 . 6 0 ± 0 . 2 8
AUC0–24 (μg·mL−1·h) 1 4 . 3 4 ± 2 . 4 2 9 . 4 7 ± 1 . 3 5

𝑡 1 / 2 𝛽 : elimination half-life; 𝐶 m a x : maximum concentration to 𝑡 m a x ; 𝑡 m a x : time of maximum concentration; AUC0–24: area under the concentration-time curve from 0 to 24 hours.