Reversible Crystallization of Argatroban after Subcutaneous Application in Pigs

Table 1

Pharmacokinetic parameters of argatroban in pigs after s.c. administration of 0.5 mg·kg⁻¹ of two different formulations of this inhibitor: sorbitol/ethanol and saline solution. Values are the mean of 𝑛=5, showing the standard deviation. ^∗𝑃<0.05; ^∗∗𝑃<0.01.

	Argatroban formulation
	Sorbitol/ethanol	Saline solution
𝑡1/2𝛽 (h)	14.46±3.91	4.38±0.43^∗
𝐶max (μg·mL^−1)	1.072±0.13	2.48±0.57^∗∗
𝑡max (h)	3.80±1.30	0.60±0.28^∗∗
AUC0–24 (μg·mL^−1·h)	14.34±2.42	9.47±1.35^∗

 𝑡_1/2𝛽: elimination half-life; 𝐶_max: maximum concentration to 𝑡_max; 𝑡_max: time of maximum concentration; AUC_0–24: area under the concentration-time curve from 0 to 24 hours.