Pathologic Etiologies of Late and Very Late Stent Thrombosis following First-Generation Drug-Eluting Stent Placement

Table 1

Incidence and underlying causes of late/very late stent thrombosis in SES and PES.

	SES	PES	𝑃 value
Incidence of late/very late ST	16/77 (21%)	25/94 (27%)	0.47
Underlying causes of late/very late ST
AMI, penetration of the necrotic core	5 (31%)	5 (20%)	0.47
Bifurcation stenting	1 (6%)	9 (36%)	0.06
Long/overlapping stents	0 (0%)	2 (8%)	0.50
Stent underexpansion	1 (6%)	1 (4%)	1.00
Isolated uncovered struts	2 (13%)	1 (4%)	0.55
Localized hypersensitivity	7 (44%)	0 (0%)	0.0005
Malapposition from excessive fibrin deposition	0 (0%)	7 (28%)	0.03

AMI: acute myocardial infarction; PES: paclitaxel-eluting stents; SES: sirolimus-eluting stents; ST: stent thrombosis (Reproduced with permission from [49].)