Table 1: Definitions of stent thrombosis according to the level of documentation and timing.

Category Description

Level of documentation

Angiographic confirmation
(1) The thrombus
 (i) Originates in the stent or within 5 mm proximal or distal from the stent
 (ii) Can be either occlusive or nonocclusive
Definite (2) And is accompanied within a 48-hour time window with:
 (i) Acute onset of ischemic symptoms in rest
 (ii) New ECG changes suggesting for acute ischemia
 (iii) Typical rise and fall in cardiac biomarkers (defined as for spontaneous MI)
Pathological confirmation
(1) Evidence of recent thrombus within the stent determined at autopsy
(2) Examination of tissue retrieved from thrombectomy

ProbableClinical definition
(1) Any unexplained death within 30 days after PCI with stent implantation
(2) Irrespective of the time after PCI with stent implantation, any MI that is related to documented acute ischemia in the territory of the implanted stent without angiographic confirmation and in the absence of any other obvious cause

PossibleClinical definition
Any unexplained death from 30 days after PCI with stent implantation until the end of trial followup

Timing after PCI with stent implantation

Acute0 to 24 hours Early onset
Subacute>24 hours to 30 days
Late>30 days to 1 year Late onset
Very late>1 year

ECG: electrocardiogram; PCI: percutaneous coronary intervention; MI: myocardial infarction.