The Role of Thrombophilia in Pregnancy

Table 4

Recommendations for inherited thrombophilia based on assigned risk category.

	High	Intermediate	Low
Type of thrombophilia	Factor V Leiden homozygous, prothrombin gene homozygous, Compound heterozygous, Antithrombin deficiency, any thrombophilia + history of VTE	Low-risk thrombophilia with a strong family history of VTE	Factor V Leiden heterozygous, prothrombin gene mutation heterozygous, protein C or S deficiency, no personal/family history of VTE
Management	Intermediate or therapeutic low molecular weight heparin antepartum and for 4–6 weeks postpartum	Prophylactic dosing of low molecular weight heparin antepartum and 4–6 weeks postpartum	Clinical surveillance antepartum and anticoagulation for 4–6 weeks postpartum

Adapted from Fogerty and Connors, 2009 [43].