Review Article

Mycobacterium bovis Bacille Calmette-Guérin as a Vaccine Vector for Global Infectious Disease Control

Table 1

Summary of candidate TB vaccines in clinical trials 2009. Nine candidate preventive TB vaccines are currently in clinical phases.

StatusProductsProduct descriptionSponsor

Phase IIbMVA85A/AERAS-485Vaccinia virus MVAOETC/AERAS
Phase IIbAERAS-402/Crucell Ad35rBCG/adenovirus 35Crucell/AERAS

Phase IIHybrid-I + IC31Ag85B/ESAT6 + adjuvantSSI/TBVI
Phase IIM72Fusion protein + adjuvantGSK/AERAS

Phase IAdAg85Aadenovirus 5/Ag85AMcMaster Univ.
Phase IVPM 1002rBCG/listeriolysin::ΔureCMax Planck/TBVI
Phase IHyvac 4/AERAS-404Fusion protein + adjuvantSSI/Sanofi/AERAS
Phase IRUTIFragmented Mtb cellArchivel Farma
Phase IHybrid-I + CAF01Ag85B/ESAT6 + adjuvantSSI

Abbreviations in the sponsors: AERAS, AERAS Global TB Vaccine Foundation; GSK, GlaxoSmithKline; OETC, The Oxford-Emergent Tuberculosis Consortium Ltd.; SSI, Staten Serum Institute; TBVI, Tuberculosis Vaccine Initiative.