Lactoferrin Augmentation of the BCG Vaccine Leads to Increased Pulmonary Integrity
Figure 1
Lactoferrin as a bridge between innate and adaptive immune function. Insult, defined as infection or inflammatory stimulation, leads to activation of the monocyte/macrophage system (MØ), including neutrophils (Nu). In the case of primary vaccination, dendritic cells (DCs) are also directly mediated. Activated neutrophils (Nu) degranulate at the site of inflammation and release lactoferrin. Depending on the magnitude and/or duration of the insult, DCs mature to express differential amounts of specific cytokines that affect local environments to subsequently promote T-cell polarization into TH1, Treg, or TH2 phenotypic populations (diagram adapted from [20]).
