Lactoferrin Augmentation of the BCG Vaccine Leads to Increased Pulmonary Integrity
Figure 4
Quantitative analysis of histopathological protective response due to lactoferrin vaccination. Quantitative assessment of BCG immunization with or without lactoferrin (at 10 or 100 μg/mouse) as described in Figure 2 revealed significant reduction in lung occlusion following aerosol infection with virulent mycobacteria at 65 days postchallenge. Quantitation of lung occlusion percent was completed using Image J (NIH) by comparing total section area with total area of granulomas. Number of animals per group ranged from 6 controls to 10 in the vaccinated groups. **; NS: no significant difference between groups.
