Antimycobacterial Activities of Novel 5-(1H-1,2,3-Triazolyl)Methyl Oxazolidinones

Table 1

In vitro antimycobacterium activity of 4N-acylpiperazinyl oxazolidinones against M. tuberculosis H37Rv.

Compd.	–R	𝐶log𝑃 values	IC90 (𝜇g/mL)	CC50 (𝜇g/mL) VERO	SI
1a	HCO	−1.1502	<0.20	>37.43	>187.1
b	CH3CO	−1.2042	<0.20	>41.64	>208.2
c	CF3CO	−0.0952	0.281	>44.23	>156.8
d	CHCl2CO	0.1218	<0.20	>45.72	>228.6
e	CH3CH2CO	−0.6752	0.334	>40.24	>120.4
f	CH3CH2OCO	0.9748	0.422	>41.84	>98.91
g	(CH3)2CHCO	−0.3662	0.283	>41.64	>146.6
h	(CH3)3COCO	1.6828	<0.20	>44.64	>223.2
i	CH3(CH2)4CO	0.9118	<0.20	>44.45	>222.2
j	cyclohexanoyl	0.8268	2.095	>45.65	>21.79
k	CH3(CH2)5CO	1.4408	<0.20	>45.85	>229.2
l	CH3(CH2)6CO	1.9698	<0.20	>47.25	>236.2
m	CH3(CH2)7CO	2.4988	<0.20	>48.65	>243.2
n	CH3(CH2)8CO	3.0278	<0.20	>50.06	>250.3
o	CH3(CH2)9CO	3.5568	<0.20	>51.46	>257.3
p		1.7208	<0.20	>48.25	>241.2
PH-27		0.6308	0.466	>34.73	>74.53
LZD		0.5321	<0.20	>33.73	>168.6
INH		−0.668	0.034	>100	>2941