Table 1: In vitro antimycobacterium activity of 4N-acylpiperazinyl oxazolidinones against M. tuberculosis H37Rv.

289136.table.001a

Compd. –R values IC90 ( g/mL) CC50 ( g/mL) VERO SI

1aHCO−1.1502<0.20>37.43>187.1
bCH3CO−1.2042<0.20>41.64>208.2
cCF3CO−0.09520.281>44.23>156.8
dCHCl2CO0.1218<0.20>45.72>228.6
eCH3CH2CO−0.67520.334>40.24>120.4
fCH3CH2OCO0.97480.422>41.84>98.91
g(CH3)2CHCO−0.36620.283>41.64>146.6
h(CH3)3COCO1.6828<0.20>44.64>223.2
iCH3(CH2)4CO0.9118<0.20>44.45>222.2
jcyclohexanoyl0.82682.095>45.65>21.79
kCH3(CH2)5CO1.4408<0.20>45.85>229.2
lCH3(CH2)6CO1.9698<0.20>47.25>236.2
mCH3(CH2)7CO2.4988<0.20>48.65>243.2
nCH3(CH2)8CO3.0278<0.20>50.06>250.3
oCH3(CH2)9CO3.5568<0.20>51.46>257.3
p289136.table.001b 1.7208 <0.20 >48.25 >241.2
PH-27289136.table.001c 0.6308 0.466 >34.73 >74.53
LZD289136.table.001d0.5321<0.20>33.73>168.6
INH289136.table.001e−0.6680.034>100>2941