Table 2: In vitro antimycobacterium activity of 4N-arylcarbonyl- and 4N-arylsulfonyl-piperazinyl oxazolidinones against M. tuberculosis H37Rv.

289136.table.002a

Compd. –R values IC90 ( g/mL) CC50 ( g/mL) VERO SI

2aPhCO0.61480.722>45.04>62.3
b4-ClPhCO1.4304<0.20>48.49>242.4
c3-NO2PhCO0.51980.759>49.54>65.27
d2-CH3PhCO1.11383.375>46.45>13.76
e3-CH3PhCO1.11380.422>46.45>110
f4-CH3PhCO1.11382.103>46.45>22.08
g2-CH3OPhCO0.83471.04>48.05>46.15
h3-CH3OPhCO0.83470.829>48.05>57.89
i4-CH3OPhCO0.83470.843>48.05>56.93
j2-furylCO−0.2092<0.20>44.04>220.2
k2-thienylCO0.39130.209>45.65>217.3
l3-pyridylCO−0.48620.236>45.14>190.4
m2-Cl 3-pyridylCO0.26411.389>48.59>34.98
3aCH3SO2−0.6042<0.20>42.44>212.2
b2-furylSO21.0658>100 (0.419)an/dn/d
cPhSO21.34485.469>48.65>8.896
d3-CH3PhSO21.8438>100 (1.024)an/dn/d
e4-CH3PhSO21.8438>100an/dn/d
PH-27289136.table.002b0.63080.466>34.73>74.53
LZD289136.table.002c0.5321<0.20>33.73>168.6
INH289136.table.002d−0.6680.034>100>2941

aConcentration that inhibited 50% growth of M. tb. (IC50).