Table 3: In vivo bioavailability of selected oxazolidinones.

Compd. ~ MIC ( g/mL) − serum ~ MIC ( g/mL) + serum Dilution factora ~ Compd in serum ( g/mL) Bioavailabilityb

1g1.13.31 : 2022low
1i3.33.300none
1o0.373.300none
2b3.33.300none
2j1.11.100none
2k1.11.100none
2l1.10.371 : 1011low
3a0.371.100none
PH-271.10.371 : 8088medium
LZD0.370.371 : 320118.4high
INH0.0140.0411 : 3204.48high

aDilution factor represents the last dilution step of the serum samples in which drug activity was still observed in the bioassay. (Drug levels in mouse serum are estimated by multiplying the dilution factor by the MIC value of the drug in absence of serum).
bRating of bioavailability: low: activity of drug can be seen in 1 or 2 wells of the bioassay; medium: activity of drug can be seen in 3 or 4 wells of the bioassay; high: activity of drug can be seen in 5 or 6 wells.