Table 5: In vivo efficacy log10 CFU reduction in bacterial load in lungs and spleen.

Test group Organ Dose mg/Kg/dy Mean ± SEM CFU reduction Activity

Untreated d13Lung n/a6.90 ± 0.11 n/a n/a
Spleen4.75 ± 0.21

Untreated d22 Lung n/a 8.06 ± 0.11 n/a n/a
Spleen6.38 ± 0.07

INH Lung 254.77 ± 0.123.29Active
Spleen2.04 ± 0.384.34Active

2l (306019) Lung 150 7.67 ± 0.22 0.39 Inactivea
Spleen6.24 ± 0.060.14 Inactivea

1g (306027) Lung 300 7.28 ± 0.14 0.78 Slightly active
Spleen5.95 ± 0.090.43Inactivea

PH-27 (306006) Lung 150 6.62 ± 0.08 1.44 Active
Spleen4.64 ± 0.211.74Active

a306027: slightly active in lung, but activity in spleen was not statistically significant.