The Role of Foxp3-Expressing Regulatory T Cells and T Helpers in Immunopathogenesis of Multidrug Resistant Pulmonary Tuberculosis

Table 3

Subpopulation composition of regulatory T cells of peripheral blood in patients suffering from pulmonary tuberculosis, depending on a clinical form of the disease and sensitivity of the causative to antituberculosis drugs (%), Me (Q ₁–Q ₃).

	Groups of patients	Relative content of regulatory T-cell subpopulations
		CD4^+CD25^+Foxp3^+	CD4^+CD25^−Foxp3^+	CD4^+CD25^+Foxp3^−
	Healthy donors	2,63	5,12	25,45
		(2,00–3,29)	(4,76–9,75)	(22,30–27,60)
ITB patients	DS TB	4,32	5,81	9,72
		(4,12–8,25)	(4,12–9,63)	(7,14–21,69)
		𝑝1=0,007		𝑝1=0,003
	MDR TB	5,08	8,41	16,27
		(3,12–7,42)	(5,62–11,58)	(9,13–25,92)
		𝑝1=0,039	𝑝1=0,005	𝑝1=0,048
			𝑝4=0,037	𝑝4=0,017
DTB patients	DS TB	5,31	5,63	13,71
		(2,84–9,48)	(3,79–8,47)	(9,64–17,08)
		𝑝1=0,015		𝑝1=0,006
	MDR TB	4,42	6,75	13,98
		(3,17–7,53)	(4,82–8,16)	(7,52–17,80)
		𝑝1=0,038		𝑝1=0,006
FCTB patients	DS TB	2,72	3,25	19,62
		(2,09–3,66)	(2,17–5,82)	(11,31–31,75)
		𝑝3=0,013	𝑝2=0,014	𝑝3=0,018
	MDR TB	6,82	12,27	17,68
		(3,17–10,42)	(8,45–13,09)	(12,42–23,19)
		𝑝1=0,003	𝑝1=0,017
		𝑝4=0,039	𝑝4=0,015

Note: 𝑝₁: the level of statistical significance of differences in comparison with features of healthy donors; 𝑝₂: in ITB patients; 𝑝₃: in DTB patients; 𝑝₄: in DS TB patients.