Isoniazid Toxicity among an Older Veteran Population: A Retrospective Cohort Study

Table 1

Characteristics of veterans with and without isoniazid discontinuation due to suspected toxicity.

Characteristic	Treatment completion (%)	Discontinuation due to suspected toxicity (%)	𝑃 value
	(𝑛=100)	(𝑛=18)
Age category			0.64
<35	5 (5)	0 (0)
35–55	49 (49)	10 (56)
56–75	35 (35)	5 (28)
>75	11 (11)	3 (17)
Sex			0.39
Male	98 (98)	17 (94)
Female	2 (2)	1 (6)
Comorbidities
HIV	9 (9)	1 (6)	0.63
Hepatitis C	17 (17)	8 (44)	0.01
Alcohol use	33 (33)	8 (44)	0.35
IDU	11 (11)	5 (28)	0.06
Initiation setting			0.18
Outpatient
Primary care clinic	33 (33)	7 (39)
Infectious disease clinic	47 (47)	6 (33)
Emergency department	3 (3)	0 (0)
Inpatient
Long-term care facility	14 (14)	2 (11)
Acute care facility	3 (3)	3 (16)