Research Article
Performance of Tuberculin Skin Test Measured against Interferon Gamma Release Assay as Reference Standard in Children
Table 2
Sensitivities and specificities of tuberculin skin test thresholds and BCG immunisation status.
| | Study reference | BCG immunisation status (immunised +, not immunised −) | Sensitivity (95% confidence interval) | Specificity (95% confidence interval) | False negative rate as percentage (95% confidence interval) of people with negative tuberculin skin test amongst IGRA positive patients |
| | TST induration threshold 5 mm | | Chun et al. 2008 [5]a | + | 86.7 (59.5 to 98.3) | 60.8 (51.8 to 69.2) | 13.3 (1.7 to 40.5) | |
Bakir et al. 2009 [1] | + | 87.4 (82.6 to 91.2) | 59.7 (54.7 to 64.5) | 12.6 (8.8 to 17.4) | | − | 89.1 (81.7 to 94.2) | 88.9 (81.0 to 94.3) | 10.9 (5.8 to 18.3) | | Soon et al. 2010 [8] | + | 100.0 (54.1 to 100.0) | 75.00 (50.9 to 91.3) | 0.0 (0.0 to 45.9) | | Méndez-Echevarría et al. 2011 [10] | − | 100.0 (95.0 to 100.0) | 93.6 ( 88.7 to 96.5) | 0.0 (0.0 to 5.0) | | Kasambira et al. 2011 [11] | + | 74.7 (63.3 to 84.0) | 92.5 (87.3 to 96.1) | 25.3 (16.0 to 36.7) |
| | TST induration threshold 10 mm | |
Dogra et al. 2007 [4] | + | 62.5 (24.5 to 91.5) | 97.4 (91.0 to 99.7) | 37.5 (8.5 to 75.5) | | − | 100.0 (29.2 to 100.0) | 100.0 (79.4 to 100.0) | 0.0 (0.0 to 70.8) | | Chun et al. 2008 [5] | + | 73.3 (44.9 to 92.2) | 81.5 (73.8 to 87.8) | 26.6 (7.8 to 55.1) | |
Bakir et al. 2009 [1] | + | 81.8 (76.5 to 86.4) | 74.9 (70.4 to 79.1) | 18.2 (13.6 to 23.5) | | − | 84.5 (76.4 to 90.7) | 91.9 (84.7 to 96.4) | 15.5 (9.3 to 23.6) | | Nicol et al. 2009 [7] | + | 87.0 (75.1 to 94.6) | 77.5 (70.2 to 83.7) | 13.0 (5.4 to 24.9) | | Soon et al. 2010 [8] | + | 66.7 (22.3 to 95.7) | 95.0 (75.1 to 99.8) | 33.3 (4.3 to 77.7) | | Stefan et al. 2010 [9] | + | 33.3 (0.008 to 90.6) | 92.3 (74.9 to 99.0) | 66.6 (9.4 to 99.2) | | Kasambira et al. 2011 [11] | + | 64.0 (52.1 to 74.8) | 95.6 (91.2 to 98.2) | 36.0 (25.2 to 47.9) | |
Méndez-Echevarría et al. 2011 [10] | + | 82.6 (63.0 to 93.0) | 86.0 (80.0 to 90.0) | 17.4 (7.0 to 37.0) | | − | 95.9 (88.6 to 98.6) | 95.5 (91.1 to 97.8) | 4.1 (1.4 to 11.4) | | Moyo et al. 2011 [12] | + | 83.8 (72.9 to 91.6) | 95.8 (92.9 to 97.7) | 16.1 (8.4 to 27.1) | | Nkurunungi et al. 2012 [13] | + | 25.0 (15.3 to 36.9) | 97.4 (94.5 to 99.0) | 75.0 (63.1 to 84.7) |
| | TST induration threshold 15 mm | | Taylor et al. 2008 [6] | + | 75.0 (19.4 to 99.4) | 70.7 (54.5 to 83.9) | 25.0 (0.6 to 80.6) | |
Bakir et al. 2009 [1] | + | 75.5 (69.7 to 80.7) | 90.5 (87.2 to 93.2) | 24.5 (19.3 to 30.3) | | − | 83.6 (75.4 to 90.0) | 97.0 (91.4 to 99.4) | 16.4 (10.0 to 24.6) | | Méndez-Echevarría et al. 2011 [10] | + | 60.9 (40.8 to 77.8) | 97.0 (92.4 to 98.2) | 39.1 (22.2 to 59.2) |
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Numbers refer to the number of the reference in References of the paper.
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