Mefloquine and Its Enantiomers Are Active against Mycobacterium tuberculosis In Vitro and in Macrophages

Table 1

Mefloquine and enantiomers MIC against two strains of MDR M. tuberculosis and H37Rv and Erdman strains. Results in mcg/mL.

Compounds	Strains
	H37Rv	Erdman	MDR Mtb
			Strain 368	Strain 400
Mefloquine	8	8	8	16
(+)Threo-mefloquine	16	16	16	32
(−)Threo-mefloquine	32	32	32	64
(+)Erythro-mefloquine	8	8	8	16
(−)Erythro-mefloquine	8	8	8	32